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苯福林

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苯福林
Skeletal formula of phenylephrine
Ball-and-stick model of the phenylephrine molecule
临床资料
读音/ˌfɛnəlˈɛfrn, f-, -ɪn/
商品名英语Drug nomenclatureNeo-synephrine, others[1]
AHFS/Drugs.comMonograph
核准状况
给药途径By mouth, in the nose, on the eye, intravenous, intramuscular
ATC码
法律规范状态
法律规范
药物动力学数据
生物利用度38% through GI tract
血浆蛋白结合率95%
药物代谢Liver (oxidative deamination)
药效起始时间英语Onset of actionVery rapid (IV); within 20 min (by mouth)[2]
生物半衰期2.1–3.4 h
作用时间Up to 20 min (IV); 4 hrs (by mouth)[2]
识别信息
  • (R)-3-[-1-hydroxy-2-(methylamino)ethyl]phenol
CAS号59-42-7  checkY
61-76-7
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.000.386 编辑维基数据链接
化学信息
化学式C9H13NO2
摩尔质量167.21 g·mol−1
3D模型(JSmol英语JSmol
  • O[C@H](c1cc(O)ccc1)CNC
  • InChI=1S/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/m0/s1 checkY
  • Key:SONNWYBIRXJNDC-VIFPVBQESA-N checkY

苯福林(英语:Phenylephrine,也称作4-去氧肾上腺素)是一种N-甲基苯乙胺衍生物,分子式C9H13NO2,可用作药物[2][3],主要治疗感冒鼻敏感所导致的鼻塞,高剂量的苯福林用来治疗低血压痔疮

参考文献

  1. ^ Phenylephrine (DB00388). DrugBank. [4 April 2015]. (原始内容存档于2015-04-16). 
  2. ^ 2.0 2.1 2.2 Phenylephrine Monograph for Professionals. Drugs.com. AHFS. 2 March 2022 [9 May 2022]. (原始内容存档于2023-06-02). However, efficacy of oral phenylephrine for this use [as a decongestant] has been questioned. 
  3. ^ British national formulary : BNF 76 76, 1140. Pharmaceutical Press. 2018: 188–189. ISBN 9780857113382. 

外部链接

  • Phenylephrine. U.S. National Library of Medicine: Drug Information Portal. [2022-12-19]. (原始内容存档于2022-05-29).