3α(17β)-羥基類固醇脫氫酶 (NAD+)
3α(17β)-羥基類固醇脫氫酶 (NAD+) | |||||||||
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識別碼 | |||||||||
EC編號 | 1.1.1.63 | ||||||||
CAS號 | 9028-62-0 | ||||||||
數據庫 | |||||||||
IntEnz | IntEnz瀏覽 | ||||||||
BRENDA | BRENDA入口 | ||||||||
ExPASy | NiceZyme瀏覽 | ||||||||
KEGG | KEGG入口 | ||||||||
MetaCyc | 代謝路徑 | ||||||||
PRIAM | 概述 | ||||||||
PDB | RCSB PDB PDBj PDBe PDBsum | ||||||||
基因本體 | AmiGO / EGO | ||||||||
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3α(17β)-羥基類固醇脫氫酶 (NAD+)(英語:3α(17β)-Hydroxysteroid dehydrogenase (NAD+),EC 1.1.1.239),原稱作睾酮17β-脫氫酶(EC 1.1.1.63),是一種以NAD+或NADP+為受體、作用於供體CH-OH基團上的氧化還原酶。這種酶能催化以下酶促反應:
3α(17β)-羥基類固醇脫氫酶 (NAD+)主要參與雄激素和雌激素代謝過程。
參考文獻
- ENDAHL GL, KOCHAKIAN CD, HAMM D. Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine nucleotide-specific 17 beta-hydroxy-(testosterone) dehydrogenase of guinea pig liver. J. Biol. Chem. 1960, 235: 2792–6. PMID 13696735.
- SWEAT ML, SAMUELS LT, LUMRY R. Preparation and characterization of the enzyme which converts testosterone to androstenedione. J. Biol. Chem. 1950, 185 (1): 75–84. PMID 15436478.
- Villee CA and Spencer JM. Some properties of the pyridine nucleotide-specific 17beta-hydroxy steroid dehydrogenase of guinea pig liver. J. Biol. Chem. 1960, 235: 3615–3619. PMID 13781425.