蛛毒素受體2

蛛毒素受體2
識別號
別名	ADGRL2；, CIRL2, CL2, LEC1, LPHH1, LPHN2, adhesion G protein-coupled receptor L2
外部ID	OMIM：607018 MGI：2139714 HomoloGene：22712 GeneCards：ADGRL2
基因位置（人類） 染色體 1號染色體 基因座 1p31.1 起始 81,306,147 bp 終止 81,993,932 bp
基因位置（小鼠） 染色體 小鼠3號染色體 基因座 3|3 H3 起始 148,815,583 bp 終止 148,990,555 bp
RNA表達模式
查閱更多表達數據
基因本體 分子功能 • G protein-coupled receptor activity • transmembrane signaling receptor activity • latrotoxin receptor activity • signal transducer activity • carbohydrate binding 細胞組分 • integral component of membrane • 膜 • 胞內 • integral component of plasma membrane • neuron projection 生物學過程 • G protein-coupled receptor signaling pathway • cell surface receptor signaling pathway • 信號轉導 • adenylate cyclase-activating G protein-coupled receptor signaling pathway • brain development Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	23266	99633
Ensembl	ENSG00000117114	ENSMUSG00000028184
UniProt	O95490	Q8JZZ7
mRNA​序列	NM_001297704 ​NM_001297705 ​NM_001297706 ​NM_012302 ​NM_001330645 ​NM_001350698 ​NM_001350699 ​NM_001366002 ​NM_001366003 ​NM_001366004 ​NM_001366005 ​NM_001366006 ​NM_001366007 ​NM_001366008 ​NM_001366009 ​NM_001393349 ​NM_001393350 ​NM_001393351 ​NM_001393352 ​NM_001393353 ​NM_001393354	NM_001081298
蛋白序列	NP_001284633 ​NP_001284634 ​NP_001284635 ​NP_001317574 ​NP_036434 ​NP_001337627 ​NP_001337628 ​NP_001352931 ​NP_001352932 ​NP_001352933 ​NP_001352934 ​NP_001352935 ​NP_001352936 ​NP_001352937 ​NP_001352938	NP_001074767 ​NP_001392915 ​NP_001392916 ​NP_001392917 ​NP_001392918 ​NP_001392919 ​NP_001392920 ​NP_001392921 ​NP_001392922 ​NP_001392923 ​NP_001392924 ​NP_001392925 ​NP_001392926 ​NP_001392927 ​NP_001392928 ​NP_001392929 ​NP_001392930 ​NP_001392931 ​NP_001392932 ​NP_001392933 ​NP_001392934 ​NP_001392935 ​NP_001392936 ​NP_001392937 ​NP_001392938 ​NP_001392939 ​NP_001392940 ​NP_001392947 ​NP_001392948
基因位置​（UCSC）	Chr 1: 81.31 – 81.99 Mb	Chr 3: 148.82 – 148.99 Mb
PubMed​查找
維基數據
檢視/編輯人類 檢視/編輯小鼠

蛛毒素受體2（英語：Latrophilin 2）是一種在人類中由ADGRL2基因編碼的蛋白質。

該基因編碼G蛋白偶聯受體（GPCR）的蛛毒素受體亞家族成員。蛛毒素受體可能在細胞黏附和信號轉導中發揮作用。在非人類物種的實驗中，富含半胱氨酸的GPS（G蛋白偶聯受體蛋白水解位點）結構域內的內源性蛋白水解切割產生兩個亞基（一個大的細胞外N末端細胞黏附亞基和一個與GPCR的促胰液素/降鈣素家族具有實質相似性的亞基）非共價結合在細胞膜上。雖然已經描述了幾種轉錄變體，但僅確定了其中一種的生物學有效性。

參見

• 黏附G蛋白偶聯受體

延申閱讀

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• Clark TA, Schweitzer AC, Chen TX, Staples MK, Lu G, Wang H, Williams A, Blume JE. Discovery of tissue-specific exons using comprehensive human exon microarrays. Genome Biology. 2007, 8 (4): R64. PMC 1896007 . PMID 17456239. doi:10.1186/gb-2007-8-4-r64.