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納米籠

維基百科,自由的百科全書
金納米籠的合成

無機納米籠(Inorganic Nanocages)通常指空心的帶孔洞的納米顆粒,大小為10到150納米。金納米籠可由氯金酸HAuCl4)在沸水中取代納米顆粒合成[1]。通常金納米顆粒的吸收峰在可見光波段(約550nm),而金納米籠的吸收峰則位於近紅外波段。近紅外光的生物組織穿透性較好,且金納米籠也有較好的生物相容性,使其能作為光學相干斷層掃描顯影劑,解像度可達微米級。金納米籠也可以通過吸收近紅外光來加熱,納米籠的最初發現者華盛頓大學的夏幼南等將腫瘤特異性的抗體(如抗EGFR的抗體)加在金納米籠上,使其可特異性富集在癌細胞表面,再遠程施加近紅外光,以光熱效應加熱殺死癌細胞[2][3]

參考文獻

  1. ^ Jingyi Chen, Fusayo Saeki, Benjamin J. Wiley, Hu Cang, Michael J. Cobb, Zhi-Yuan Li, Leslie Au, Hui Zhang, Michael B. Kimmey, Xingde Li, and Younan Xia. Gold Nanocages: Bioconjugation and Their Potential Use as Optical Imaging Contrast Agents. Nano Lett. 2005, 5 (3): 473–7. PMID 15755097. doi:10.1021/nl047950t. 
  2. ^ Jingyi Chen, Danling Wang, Jiefeng Xi , Leslie Au, Andy Siekkinen, Addie Warsen, Zhi-Yuan Li, Hui Zhang, Younan Xia, and Xingde Li. Gold Nanocages: Bioconjugation and Their Potential Use as Optical Imaging Contrast Agents. Nano Lett. 2007, 7 (5): 1318–22. PMID 17430005. doi:10.1021/nl070345g. 
  3. ^ Jingyi Chen, Charles Glaus, Richard Laforest, Qiang Zhang, Miaoxian Yang, Michael Gidding, Michael J. Welch, and Younan Xia. Gold Nanocages as Photothermal Transducers for Cancer Treatment. Small. 2010, 6 (7): 811–7. PMID 20225187. doi:10.1002/smll.200902216.