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纳米笼

维基百科,自由的百科全书
金纳米笼的合成

无机纳米笼(Inorganic Nanocages)通常指空心的带孔洞的纳米颗粒,大小为10到150纳米。金纳米笼可由氯金酸HAuCl4)在沸水中取代纳米颗粒合成[1]。通常金纳米颗粒的吸收峰在可见光波段(约550nm),而金纳米笼的吸收峰则位于近红外波段。近红外光的生物组织穿透性较好,且金纳米笼也有较好的生物相容性,使其能作为光学相干断层扫描显影剂,分辨率可达微米级。金纳米笼也可以通过吸收近红外光来加热,纳米笼的最初发现者华盛顿大学的夏幼南等将肿瘤特异性的抗体(如抗EGFR的抗体)加在金纳米笼上,使其可特异性富集在癌细胞表面,再远程施加近红外光,以光热效应加热杀死癌细胞[2][3]

参考文献

  1. ^ Jingyi Chen, Fusayo Saeki, Benjamin J. Wiley, Hu Cang, Michael J. Cobb, Zhi-Yuan Li, Leslie Au, Hui Zhang, Michael B. Kimmey, Xingde Li, and Younan Xia. Gold Nanocages: Bioconjugation and Their Potential Use as Optical Imaging Contrast Agents. Nano Lett. 2005, 5 (3): 473–7. PMID 15755097. doi:10.1021/nl047950t. 
  2. ^ Jingyi Chen, Danling Wang, Jiefeng Xi , Leslie Au, Andy Siekkinen, Addie Warsen, Zhi-Yuan Li, Hui Zhang, Younan Xia, and Xingde Li. Gold Nanocages: Bioconjugation and Their Potential Use as Optical Imaging Contrast Agents. Nano Lett. 2007, 7 (5): 1318–22. PMID 17430005. doi:10.1021/nl070345g. 
  3. ^ Jingyi Chen, Charles Glaus, Richard Laforest, Qiang Zhang, Miaoxian Yang, Michael Gidding, Michael J. Welch, and Younan Xia. Gold Nanocages as Photothermal Transducers for Cancer Treatment. Small. 2010, 6 (7): 811–7. PMID 20225187. doi:10.1002/smll.200902216.