磷酸甘油酸脫氫酶

磷酸甘油酸脫氫酶
命名 系統命名 3-phospho-D-glycerate:NAD+ 2-oxidoreductase 縮寫 PHGDH 別名 D-3-phosphoglycerate:NAD+ oxidoreductase; α-phosphoglycerate dehydrogenase; 3-phosphoglycerate dehydrogenase; 3-phosphoglyceric acid dehydrogenase; D-3-phosphoglycerate dehydrogenase; glycerate 3-phosphate dehydrogenase; glycerate-1,3-phosphate dehydrogenase; phosphoglycerate oxidoreductase; phosphoglyceric acid dehydrogenase; SerA; 3-phosphoglycerate:NAD+ 2-oxidoreductase; SerA 3PG dehydrogenase; 3PHP reductase; αKG reductase; D- and L-HGA
識別碼
EC編號	1.1.1.95
CAS號	9075-29-0
數據庫
IntEnz	IntEnz瀏覽
BRENDA	BRENDA入口
ExPASy	NiceZyme瀏覽
KEGG	KEGG入口
MetaCyc	代謝路徑
PRIAM	概述
PDB	RCSB PDB PDBj PDBe PDBsum
基因本體	AmiGO / EGO
搜索 PMC 相關文獻 PubMed 相關文獻

磷酸甘油酸脫氫酶
磷酸甘油酸的晶體結構（PDB 2g76）
有效結構 PDB 直系同源檢索：PDBe, RCSB PDB查詢代碼列表 2G76
標識
代號	PHGDH; 3-PGDH; 3PGDH; PDG; PGAD; PGD; PGDH; SERA
擴展標識	遺傳學：606879 鼠基因：1355330 同源基因：39318 GeneCards: PHGDH Gene
EC編號	1.1.1.95
基因本體論描述 分子功能 · phosphoglycerate dehydrogenase activity · phosphoglycerate dehydrogenase activity · electron carrier activity · NAD binding 細胞成分 · cytosol 生物過程 · glutamine metabolic process · glycine metabolic process · L-serine biosynthetic process · L-serine biosynthetic process · threonine metabolic process · brain development · cellular amino acid biosynthetic process · gamma-aminobutyric acid metabolic process · regulation of gene expression · taurine metabolic process · spinal cord development · glial cell development · neural tube development · cell cycle process · neuron projection development · cellular nitrogen compound metabolic process · small molecule metabolic process Sources: Amigo / QuickGO
RNA表達模式
更多表達數據
直系同源體
物種	人類	小鼠
Entrez	26227	236539
Ensembl	ENSG00000092621	ENSMUSG00000053398
UniProt	O43175	Q61753
mRNA序列	NM_006623.3	NM_016966.3
蛋白序列	NP_006614.2	NP_058662.2
基因位置	Chr 1: 120.2 – 120.29 Mb	Chr 3: 98.12 – 98.14 Mb
PubMed查詢	[1]	[2]

磷酸甘油酸脫氫酶（英語：phosphoglycerate dehydrogenase，EC 1.1.1.95 （頁面存檔備份，存於互聯網檔案館）），是一種以NAD⁺或NADP⁺為受體、作用於供體CH-OH基團上的氧化還原酶。這種酶能催化以下兩種酶促反應：

3-磷酸化-D-甘油酸 + NAD⁺ $\rightleftharpoons$ 3-磷酸羥基丙酮酸 + NADH + H⁺

2-羥基戊二酸 + NAD⁺ $\rightleftharpoons$ α-酮戊二酸 + NADH + H⁺

在大腸桿菌（Escherichia coli）中，磷酸甘油酸脫氫酶參與催化絲氨酸生物合成的磷酸絲氨酸途徑中的第一步，上述可逆反應主要逆向進行。磷酸甘油酸脫氫酶可被絲氨酸或甘氨酸抑制。這種酶很不尋常，因為它還能像D-2-羥基戊二酸脫氫酶和L-2-羥基戊二酸脫氫酶一樣還原α-酮戊二酸，其中，D型底物更適合磷酸甘油酸脫氫酶。

參考文獻

• Sugimoto, E. and Pizer, L.I. The mechanism of end product inhibition of serine biosynthesis. I. Purification and kinetics of phosphoglycerate dehydrogenase. J. Biol. Chem. 1968, 243: 2081–1089. PMID 4384871. 
• Schuller, D.J., Grant, G.A. and Banaszak, L.J. The allosteric ligand site in the V_max-type cooperative enzyme phosphoglycerate dehydrogenase. Nat. Struct. Biol. 1995, 2: 69–76. PMID 7719856. 

擴展閱讀

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• Pind S, Slominski E, Mauthe J; et al. V490M, a common mutation in 3-phosphoglycerate dehydrogenase deficiency, causes enzyme deficiency by decreasing the yield of mature enzyme.. J. Biol. Chem. 2002, 277 (9): 7136–7143. PMID 11751922. doi:10.1074/jbc.M111419200.  引文格式1維護：顯式使用等標籤 (link)
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• Jaeken J, Detheux M, Van Maldergem L; et al. 3-Phosphoglycerate dehydrogenase deficiency: an inborn error of serine biosynthesis.. Arch. Dis. Child. 1996, 74 (6): 542–545. PMC 1511571 . PMID 8758134. doi:10.1136/adc.74.6.542.  引文格式1維護：顯式使用等標籤 (link)