組織蛋白酶L1
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組織蛋白酶L1(英語:Cathepsin L1)是人類體內由CTSL1基因編碼的蛋白質。[3][4][5]該蛋白質是木瓜樣蛋白酶,是一種溶體半胱胺酸蛋白酶,在細胞內蛋白質分解代謝中起著主要的作用。[6][7][8][9]
作用
組織蛋白酶L1是肽酶C1(組織蛋白酶)MEROPS家族的成員。組織蛋白酶L1在包括正常溶體介導的蛋白質周轉、抗原、前蛋白加工以及細胞凋亡在內的多種過程中發揮重要的作用。[10]其受質包括膠原蛋白、彈性蛋白和SERPINA1,這是嗜中性球彈性蛋白酶活性的主要控制元素。組織蛋白酶L1與多種病理過程有關,包括肌病、冠狀動脈疾病中的肌原纖維壞死以及腎小管對蛋白尿的反應。它是由二硫鍵連接的重鏈和輕鏈組成的二聚體,均由單一蛋白質前體產生。已發現該基因至少有兩種編碼相同蛋白質的轉錄變體。[5]
病毒進入
病毒進入細胞需要2型新冠病毒S2棘蛋白的裂解。此過程可以通過位於細胞膜上的蛋白酶——跨膜絲胺酸蛋白酶2或內溶體中的組織蛋白酶(主要是組織蛋白酶L1)來完成。[11]羥氯喹可以抑制內溶體中組織蛋白酶L1的作用,但由於與跨膜絲胺酸蛋白酶2裂解相比,組織蛋白酶L1的裂解較小,因此羥氯喹對2型新冠病毒感染的抑制作用很小。[11]
炎症
雖然組織蛋白酶L1通常被表徵為溶體蛋白酶,但它可以被分泌,導致病理性炎症。[12]組織蛋白酶L1和其他木瓜樣蛋白酶在引起病理性炎症時往往由巨噬細胞和其他侵入組織的免疫細胞分泌而出。[13]
交互作用
組織蛋白酶L1已被證明與胱抑素A有相互作用。[14][15]
分布
組織蛋白酶L1已在許多生物體中發現,包括魚類[16]、鳥類、哺乳動物和海綿。[17]
參見
參考文獻
- ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000135047 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
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- ^ Joseph LJ, Chang LC, Stamenkovich D, Sukhatme VP. Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts. J Clin Invest. Jun 1988, 81 (5): 1621–9. PMC 442598
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- ^ 5.0 5.1 Entrez Gene: CTSL1 cathepsin L1.
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- ^ Barrett AJ, Buttle DJ, Mason RW. Lysosomal cysteine proteinases. ISI Atlas of Science. Biochemistry. 1988, 1: 256–260.
- ^ Joseph LJ, Chang LC, Stamenkovich D, Sukhatme VP. Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts. The Journal of Clinical Investigation. May 1988, 81 (5): 1621–1629. PMC 442598
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- ^ Dickinson DP. Cysteine Peptidases of Mammals: Their Biological Roles and Potential Effects in the Oral Cavity and Other Tissues in Health and Disease. Critical Reviews in Oral Biology and Medicine. 2002, 13 (3): 238–75. PMID 12090464. doi:10.1177/154411130201300304.
- ^ 11.0 11.1 Jackson CB, Farzan M, Chen B, Choe H. Mechanisms of SARS-CoV-2 entry into cells. Nature Reviews. Molecular Cell Biology. January 2022, 23 (1): 3–20. PMC 8491763
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- ^ Gomes CP, Fernandes DE, Casimiro F, da Mata GF, Passos MT, Varela P, et al. Cathepsin L in COVID-19: From Pharmacological Evidences to Genetics. Frontiers in Cellular and Infection Microbiology. 2022, 10: 589505. PMC 7753008
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- ^ Berdowska I, Matusiewicz M. Cathepsin L, transmembrane peptidase/serine subfamily member 2/4, and other host proteases in COVID-19 pathogenesis - with impact on gastrointestinal tract. World Journal of Gastroenterology. October 2021, 27 (39): 6590–6600. PMC 8554394
. PMID 34754154. doi:10.3748/wjg.v27.i39.6590.
- ^ Majerle, Andreja; Jerala Roman. Protein inhibitors form complexes with procathepsin L and augment cleavage of the propeptide. Arch. Biochem. Biophys. Sep 2003, 417 (1): 53–8. ISSN 0003-9861. PMID 12921779. doi:10.1016/S0003-9861(03)00319-9.
- ^ Estrada, S; Nycander M; Hill N J; Craven C J; Waltho J P; Björk I. The role of Gly-4 of human cystatin A (stefin A) in the binding of target proteinases. Characterization by kinetic and equilibrium methods of the interactions of cystatin A Gly-4 mutants with papain, cathepsin B, and cathepsin L. Biochemistry. May 1998, 37 (20): 7551–60. ISSN 0006-2960. PMID 9585570. doi:10.1021/bi980026r.
- ^ Venkatesh K, Prasanth B, Rajesh P, Annie JG, Mukesh P, Jesu A. A murrel cysteine protease, cathepsin L: bioinformatics characterization, gene expression and proteolytic activity. Biologia. 2014, 39 (3): 395–406. doi:10.2478/s11756-013-0326-8
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- ^ Sevenich L, Pennacchio LA, Peters C, Reinheckel T. Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice. Biological Chemistry. July 2006, 387 (7): 885–91 [2022-10-31]. PMID 16913838. S2CID 27739485. doi:10.1515/BC.2006.112. (原始內容存檔於2022-10-31).
拓展閱讀
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外部連結
- The MEROPS online database for peptidases and their inhibitors: C01.032[失效連結]
- 醫學主題詞表(MeSH):Cathepsin+L
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