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生長激素受體

維基百科，自由的百科全書
Growth hormone receptor
生長激素受體
PDB rendering based on 1a22.
有效結構
PDB 直系同源檢索：PDBe, RCSB
標識
代號 GHR; GHBP
擴展標識 遺傳學：600946 鼠基因：95708 同源基因：134 ChEMBL: 1976 GeneCards: GHR Gene
RNA表達模式
更多表達數據
直系同源體
物種 人類 小鼠
Entrez 2690 14600
Ensembl ENSG00000112964 ENSMUSG00000055737
UniProt P10912 P16882
mRNA序列 NM_000163 NM_001048147
蛋白序列 NP_000154 NP_001041612
基因位置 Chr 5:
42.42 – 42.72 Mb		 Chr 15:
3.32 – 3.58 Mb
PubMed查詢 [1] [2]

生長激素受體（英語：Growth hormone receptor)是一種由人類基因GHR 編碼的蛋白質[1]，GHR的直系同源物[2]廣泛存在於各種哺乳動物中。

此基因編碼的蛋白是結合生長激素的跨膜受體。

相互作用

生長激素受體能與SGTA[3]、PTPN11[4][5]、JAK激酶2[6][7][8]、SOCS1[9]和CISH[9]發生交互作用。

進化

GHR 基因曾作為動物核DNA（英語：nuclear DNA）系統發育標記[2]，對其10號外顯子基因多態性的探究第一次闡釋了齧齒目主要類群間的親緣關係[10][11][12]。GHR也用於較低階元的分類，在鼠總科[13][14]、八齒鼠科[15]、田鼠亞科[16]、鼠亞科（英語：Murinae）[17]、白足鼠屬[18]等齧齒動物，及熊型總科[19]、貓科[20]等肉食動物以及皮翼目[21]的分類上有重要作用。GHR的9號內含子也用於闡釋鼬科[22]、鬣狗科[23]的系統發生。

拮抗劑

參考文獻

  1. ^ Entrez Gene: GHR growth hormone receptor. 
  2. ^ 2.0 2.1 OrthoMaM phylogenetic marker: GHR coding sequence. [2014-02-04]. （原始內容存檔於2015-09-24）. 
  3. ^ Schantl, Julia A; Roza Marcel, De Jong Ad P, Strous Ger J. Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) interacts with the ubiquitin-dependent endocytosis (UbE) motif of the growth hormone receptor. Biochem. J. (England). August 2003, 373 (Pt 3): 855–63. ISSN 0264-6021. PMC 1223544 可免費查閱. PMID 12735788. doi:10.1042/BJ20021591. 
  4. ^ Stofega, M R; Herrington J, Billestrup N, Carter-Su C. Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B. Mol. Endocrinol. (UNITED STATES). September 2000, 14 (9): 1338–50. ISSN 0888-8809. PMID 10976913. doi:10.1210/me.14.9.1338. 
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  21. ^ Janecka J. E., Helgen K. M., Lim N. T., Baba M., Izawa M., Boeadi & Murphy W. J. Evidence for multiple species of Sunda colugo. Curr. Biol. 2008, 18 (21): R1001–R1002. PMID 19000793. doi:10.1016/j.cub.2008.09.005. 
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外部連結


取自「https://zh.wikipedia.org/w/index.php?title=生长激素受体&oldid=69710465」