心臟肥大 (英語:Cardiomegaly),有時稱大心臟 或簡稱心肥大 ,是一種心臟擴大 的疾病。它通常是因為某些因素而使心臟更加用力跳動而造成的的結果,例如肥胖 、心臟瓣膜疾病 、高血壓 和冠狀動脈疾病 。心肌病 也與心臟肥大有關。[ 12]
心臟肥大可能很嚴重,具體取決於心臟擴大的部位,並可能導致充血性心力衰竭 。最近的研究表明,心臟肥大與更高的心源性猝死 風險相關[ 13] 。心衰竭 隨著年齡的增長而增加,男性比女性更常見,非洲裔美國人 比其他種族更常見。根據一些研究,被診斷患有心力衰竭的人中有一半在被診斷出後五年內死亡。[ 14]
心臟肥大可能會隨著時間的推移而改善,但許多心臟擴大(擴張型心肌病)的人需要終生接受藥物治療。有一個患有或患有心臟肥大的直系親屬可能表明一個人更容易患上這種疾病。[ 15]
參考文獻
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^ Hershberger, Ray E; Morales, Ana; Siegfried, Jill D. Clinical and genetic issues in dilated cardiomyopathy: A review for genetics professionals . Genetics in Medicine. 22 September 2010, 12 (11): 655–667. PMC 3118426 . PMID 20864896 . doi:10.1097/GIM.0b013e3181f2481f .
^ Luk, A; Ahn, E; Soor, G S; Butany, J. Dilated cardiomyopathy: a review. Journal of Clinical Pathology. 18 November 2008, 62 (3): 219–225. PMID 19017683 . S2CID 28182534 . doi:10.1136/jcp.2008.060731 .
^ What Is an Enlarged Heart (Cardiomegaly)? . WebMD. 2019-01-30 [2019-03-29 ] . (原始內容 存檔於2022-03-24).
^ Lee, Ji Eun; Oh, Jin-Hee; Lee, Jae Young; Koh, Dae Kyun. Massive Cardiomegaly due to Dilated Cardiomyopathy Causing Bronchial Obstruction in an Infant . Journal of Cardiovascular Ultrasound. 2014, 22 (2): 84–7. PMC 4096670 . PMID 25031799 . doi:10.4250/jcu.2014.22.2.84 .
^ Marian, Ali J.; Braunwald, Eugene. Hypertrophic Cardiomyopathy . Circulation Research. 15 September 2017, 121 (7): 749–770. PMC 5654557 . PMID 28912181 . doi:10.1161/CIRCRESAHA.117.311059 .
^ Maron, Martin S. Clinical Utility of Cardiovascular Magnetic Resonance in Hypertrophic Cardiomyopathy . Journal of Cardiovascular Magnetic Resonance. 1 February 2012, 14 (1): 13. PMC 3293092 . PMID 22296938 . doi:10.1186/1532-429X-14-13 .
^ Almog, C; Weissberg, D; Herczeg, E; Pajewski, M. Thymolipoma simulating cardiomegaly: a clinicopathological rarity. . Thorax. 1 February 1977, 32 (1): 116–120. PMC 470537 . PMID 138960 . doi:10.1136/thx.32.1.116 .
^ Hou, Jianglong; Kang, Y. James. Regression of pathological cardiac hypertrophy: Signaling pathways and therapeutic targets . Pharmacology & Therapeutics. September 2012, 135 (3): 337–354. PMC 3458709 . PMID 22750195 . doi:10.1016/j.pharmthera.2012.06.006 .
^ Luis Fuentes, Virginia; Wilkie, Lois J. Asymptomatic Hypertrophic Cardiomyopathy (PDF) . Veterinary Clinics of North America: Small Animal Practice. September 2017, 47 (5): 1041–1054 [2022-05-07 ] . PMID 28662873 . doi:10.1016/j.cvsm.2017.05.002 . (原始內容 (PDF) 存檔於2021-01-22).
^ Maron, Barry J; Maron, Martin S. Hypertrophic cardiomyopathy. The Lancet. January 2013, 381 (9862): 242–255. PMID 22874472 . S2CID 38333896 . doi:10.1016/S0140-6736(12)60397-3 .
^ Overview of Cardiomyopathies . The Lecturio Medical Concept Library. [25 August 2021] . (原始內容 存檔於2022-05-01).
^ Tavora F; et al. Cardiomegaly is a common arrhythmogenic substrate in adult sudden cardiac deaths and is associated with obesity.. Pathology. 2012, 44 (3): 187–91. PMID 22406485 . S2CID 25422195 . doi:10.1097/PAT.0b013e3283513f54 .
^ Warner, Jennifer. Heart Failure Patients Too Optimistic . WebMD. [2022-03-17 ] . (原始內容 存檔於2022-06-23) (英語) .
^ Enlarged heart - Symptoms and causes . mayoclinic.org. [19 March 2018] . (原始內容 存檔於2016-12-02).
外部連結