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STAT1

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维基百科,自由的百科全书
STAT1
已知的结构
PDB直系同源搜索: PDBe RCSB
识别号
别名STAT1;, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1
外部IDOMIM600555 MGI103063 HomoloGene21428 GeneCardsSTAT1
相关疾病
慢性黏膜皮肤念珠菌病、​susceptibility to viral and mycobacterial infections[1]
基因位置(人类
2号染色体
染色体2号染色体[2]
2号染色体
STAT1的基因位置
STAT1的基因位置
基因座2q32.2起始190,908,460 bp[2]
终止191,020,960 bp[2]
RNA表达模式
查阅更多表达数据
直系同源
物种人类小鼠
Entrez
Ensembl
UniProt
mRNA​序列

​NM_007315
​NM_139266

NM_001205313
​NM_001205314
​NM_009283
​NM_001357627

蛋白序列

NP_009330
​NP_644671

无数据

基因位置​(UCSC)Chr 2: 190.91 – 191.02 MbChr 1: 52.16 – 52.2 Mb
PubMed​查找[4][5]
维基数据
查看/编辑人类查看/编辑小鼠

STAT1转录因子信号转导及转录激活蛋白(STAT蛋白)家族的一员。

STAT1涉及I型II型III型干扰素激活基因的正调控。在干扰素-γ刺激下,STAT1会组成同源二聚体或与STAT3组成异二聚体结合到GAS(Interferon-Gamma-Activated Sequence,干扰素γ激活序列)启动子上;而在干扰素-α或干扰素-β刺激下,STAT1会与STAT2组成异二聚体结合到ISREInterferon-Stimulated Response Element,干扰素激活反应元件)启动子上[6]。在这两种情况下,STAT二聚体与启动子的结合都会导致ISGInterferon-Stimulated Genes,干扰素激活基因)的表达。

STAT1可由二烯丙基二硫诱导表达[7]

相互作用

STAT1能与下列蛋白质发生相互作用

参考文献

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  5. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
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