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NEUROD1

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NEUROD1
已知的结构
PDB直系同源搜索: PDBe RCSB
识别号
别名NEUROD1;, BETA2, BHF-1, MODY6, NEUROD, bHLHa3, neuronal differentiation 1, T2D
外部IDOMIM601724 MGI1339708 HomoloGene1871 GeneCardsNEUROD1
基因位置(人类
2号染色体
染色体2号染色体[1]
2号染色体
NEUROD1的基因位置
NEUROD1的基因位置
基因座2q31.3起始181,668,295 bp[1]
终止181,680,827 bp[1]
RNA表达模式
查阅更多表达数据
直系同源
物种人类小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_002500

NM_010894

蛋白序列

NP_002491

NP_035024

基因位置​(UCSC)Chr 2: 181.67 – 181.68 MbChr 2: 79.28 – 79.29 Mb
PubMed​查找[3][4]
维基数据
查看/编辑人类查看/编辑小鼠

NEUROD1,(小鼠的同源蛋白质记为NeuroD1)在人体内是NeuroD蛋白家族下的一个转录因子,由NEUROD1基因编码。NEUROD1在神经系统发育中扮演重要角色,于发育中参与调控多种神经系细胞的分化过程[5][6]

证据表明NEUROD1与II型糖尿病的发生关系密切[7]。一项研究表明在小鼠大脑内过表达NEUROD1可使神经胶质细胞转分化为神经元[8]

蛋白质相互作用

已知NEUROD1会和周期蛋白D1[9]MAFA[10]MAP3K10[11]发生相互作用

参考

  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000162992 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000034701 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Poulin, G; Turgeon, B; Drouin, J. NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene. Molecular and Cellular Biology. 1997-11, 17 (11): 6673–6682 [2021-11-10]. ISSN 0270-7306. PMC 232521可免费查阅. PMID 9343431. doi:10.1128/MCB.17.11.6673. (原始内容存档于2021-11-10) (英语). 
  6. ^ NEUROD1. UniProt. [2018-02-25]. (原始内容存档于2018-02-25). 
  7. ^ NEUROD1 neuronal differentiation 1 [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2021-11-10]. (原始内容存档于2021-11-10). 
  8. ^ Guo, Ziyuan; Zhang, Lei; Wu, Zheng; Chen, Yuchen; Wang, Fan; Chen, Gong. In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model. Cell Stem Cell. 2014-02, 14 (2): 188–202 [2021-11-10]. PMC 3967760可免费查阅. PMID 24360883. doi:10.1016/j.stem.2013.12.001. (原始内容存档于2022-02-17) (英语). 
  9. ^ Ratineau, Christelle; Petry, Mary W.; Mutoh, Hiroyuki; Leiter, Andrew B. Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD. The Journal of Biological Chemistry. 2002-03-15, 277 (11): 8847–8853 [2021-11-10]. ISSN 0021-9258. PMID 11788592. doi:10.1074/jbc.M110747200. (原始内容存档于2021-11-10). 
  10. ^ Zhao, Li; Guo, Min; Matsuoka, Taka-Aki; Hagman, Derek K.; Parazzoli, Susan D.; Poitout, Vincent; Stein, Roland. The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription. The Journal of Biological Chemistry. 2005-03-25, 280 (12): 11887–11894 [2021-11-10]. ISSN 0021-9258. PMID 15665000. doi:10.1074/jbc.M409475200. (原始内容存档于2022-04-19). 
  11. ^ Marcora, E.; Gowan, K.; Lee, J. E. Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2. Proceedings of the National Academy of Sciences. 2003-08-05, 100 (16): 9578–9583. ISSN 0027-8424. PMC 170960可免费查阅. PMID 12881483. doi:10.1073/pnas.1133382100 (英语).