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A20细胞

维基百科,自由的百科全书

A20 (亦称ATCC TIB-208) 是于1979年在BALB/c小鼠发现的B细胞淋巴瘤细胞系[1],该球状淋巴母细胞英语Lymphoblast表面光滑且中心部分较暗边缘明显,较常应用于存在免疫缺陷及具有免疫功能的动物模型构建[2][3],以进行疫苗靶点的选择、研究抗肿瘤免疫机制和筛选药物[4][5][6],由A20细胞所建立的模型的病理学特征与人类弥漫大B细胞淋巴瘤非常类似。

参考资料

  1. ^ Kim, KJ; Kanellopoulos-Langevin, C; Merwin, RM; Sachs, DH; Asofsky, R. Establishment and characterization of BALB/c lymphoma lines with B cell properties.. Journal of immunology (Baltimore, Md. : 1950). 1979-02, 122 (2): 549–554 [2019-12-05]. PMID 310843. 
  2. ^ Küppers, R; Hansmann, ML. The Hodgkin and Reed/Sternberg cell.. The international journal of biochemistry & cell biology. 2005-03, 37 (3): 511–517 [2019-12-05]. PMID 15618006. doi:10.1016/j.biocel.2003.10.025. 
  3. ^ Yanagisawa, Y; Sato, Y; Asahi-Ozaki, Y; Ito, E; Honma, R; Imai, J; Kanno, T; Kano, M; Akiyama, H; Sata, T; Shinkai-Ouchi, F; Yamakawa, Y; Watanabe, S; Katano, H. Effusion and solid lymphomas have distinctive gene and protein expression profiles in an animal model of primary effusion lymphoma.. The Journal of pathology. 2006-2008, 209 (4): 464–73 [2019-12-05]. PMID 16741895. doi:10.1002/path.2012. 
  4. ^ Meziane el, K; Bhattacharyya, T; Armstrong, AC; Qian, C; Hawkins, RE; Stern, PL; Dermime, S. Use of adenoviruses encoding CD40L or IL-2 against B cell lymphoma.. International journal of cancer. 2004-10-10, 111 (6): 910–920 [2019-12-05]. PMID 15300803. doi:10.1002/ijc.20332. 
  5. ^ Siegel, S; Wagner, A; Kabelitz, D; Marget, M; Coggin J, Jr; Barsoum, A; Rohrer, J; Schmitz, N; Zeis, M. Induction of cytotoxic T-cell responses against the oncofetal antigen-immature laminin receptor for the treatment of hematologic malignancies.. Blood. 2003-12-15, 102 (13): 4416–23 [2019-12-05]. PMID 12869512. doi:10.1182/blood-2003-01-0198. 
  6. ^ Siegel, S; Wagner, A; Schmitz, N; Zeis, M. Induction of antitumour immunity using survivin peptide-pulsed dendritic cells in a murine lymphoma model.. British journal of haematology. 2003-09, 122 (6): 911–4 [2019-12-05]. PMID 12956760. doi:10.1046/j.1365-2141.2003.04535.x. 

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