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2-氨基-5-甲氧基茚满

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2-氨基-5-甲氧基茚满
临床资料
商品名英语Drug nomenclaturenone
其他名称5-MeO-AI; 2,3-Dihydro-5-methoxy-1H-Inden-2-amine
给药途径Oral
法律规范状态
法律规范
  • NpSG
  • PSA
  • Unscheduled
药物动力学数据
生物利用度high
药物代谢acetyl-aminoindandane
生物半衰期non-linear
排泄途径full
识别信息
  • 5-Methoxy-2-aminoindane
CAS号73305-09-6  checkY
PubChem CID
ChemSpider
UNII
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C10H13NO
摩尔质量163.22 g·mol−1
3D模型(JSmol英语JSmol
  • COC1=CC2=C(CC(C2)N)C=C1
  • InChI=1S/C10H13NO/c1-12-10-3-2-7-4-9(11)5-8(7)6-10/h2-3,6,9H,4-5,11H2,1H3
  • Key:HLXHCNWEVQNNKA-UHFFFAOYSA-N

2-氨基-5-甲氧基茚满是一种有机化合物,化学式为C10H13NO。它是一种消遣性药物和预防酗酒的药物,最初于1998年在专利中以Markush结构被隐匿提及。[1]它可以5-甲氧基茚满-2-酮[2]或5-溴茚满-2-醇[3]为原料制得。它和盐酸反应,可以得到2-氨基-5-甲氧基茚满盐酸盐。[4]

参考文献

  1. ^ US 5708018,Haadsma-Svensson, Susanne R.; Bengt R. Andersson & Clas A. Sonesson et al.,“2-aminoindans as selective dopamine D3 ligands”,发表于1998-01-13,指定于Pharmacia & Upjohn Co. 
  2. ^ Renhowe, Paul A.; Chu, Daniel; Boyce, Rustum; Ni, Zhi-jie; Duhl, David; Tozzo, Effie; Johnson, Kirk; Myles, David. Preparation of guanidinobenzamides as melanocortin-4 receptor agonists useful for treating diseases such obesity and type II diabetes. 2002 WO 2002018327 A2.
  3. ^ Yusuf Akbaba, Süleyman Göksu, Ertan Şahin, Hamdullah Kılıç, Hasan Seçen. Synthesis and asymmetric resolution of a dopaminergic compound: 2-amino-5-methoxyindane. Tetrahedron: Asymmetry. 2016-07, 27 (11-12): 475–479 [2022-08-03]. doi:10.1016/j.tetasy.2016.04.005. (原始内容存档于2022-02-16) (英语). 
  4. ^ Chen, Xiaoli; Demarest, Keith T.; Lee, Jung; Matthews, Jay M.; Rybczynski, Philip. Preparation of substituted indanes and tetralins as PPARα modulators for treating Syndrome X. 2006 US 20060094786 A1.