CXCL7

Pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
Pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
	PDB rendering based on 1f9p.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1F9P, 1NAP, 1TVX
标识
代号	PPBP; B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII; CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; SCYB7; TC1; TC2; TGB; TGB1; THBGB; THBGB1
扩展标识	遗传学：121010 鼠基因：1888712 同源基因：48122 GeneCards: PPBP Gene
基因本体论描述
分子功能	· glucose transmembrane transporter activity; · chemokine activity; · growth factor activity;
细胞成分	· extracellular region; · extracellular space; · platelet alpha granule lumen;
生物过程	· platelet degranulation; · blood coagulation; · glucose transport; · platelet activation; · neutrophil chemotaxis; · defense response to bacterium; · neutrophil degranulation; · positive regulation of cell division;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	5473
Ensembl	ENSG00000163736
UniProt	P02775
mRNA序列	NM_002704
蛋白序列	NP_002695
基因位置	Chr 4:; 74.85 – 74.85 Mb
PubMed查询	[1]
	查; 论; 编;

趋化因子CXCL7（英语：Chemokine (C-X-C motif) ligand 7，CXCL7）是一个人类基因^[1]。其编码的蛋白质为趋化因子（C-X-C基序）配体7 Chemokine (C-X-C motif) ligand，是一种CXC趋化因子类细胞因子，其蛋白异型体为β-血小板球蛋白或原血小板碱性蛋白（英语：Pro-Platelet basic protein，PPBP）^[2]。

这种蛋白在血小板活化时被大量释放^[3] ，能刺激多种过程，包括有丝分裂、细胞外基质的合成、糖代谢（英语：glucose metabolism）和纤溶酶原激活物的合成^[4]^[5]。

参考文献

^ Entrez Gene: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7). （原始内容存档于2019-09-24）.
^ Hristov M, Zernecke A, Bidzhekov K; et al. Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury. Circ. Res. March 2007, 100 (4): 590–7. PMID 17272812. doi:10.1161/01.RES.0000259043.42571.68.
^ Majumdar S, Gonder D, Koutsis B, Poncz M. Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4. J Biol Chem. 1991, 266 (9): 5785–9. PMID 1826003.
^ Castor C, Miller J, Walz D. Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor. Proc Natl Acad Sci USA. 1983, 80 (3): 765–9. PMC 393460 . PMID 6572368. doi:10.1073/pnas.80.3.765.
^ Castor C, Furlong A, Carter-Su C. Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III. Biochemistry. 1985, 24 (7): 1762–7. PMID 4005226. doi:10.1021/bi00328a029.

延伸阅读

Begg GS, Pepper DS, Chesterman CN, Morgan FJ. Complete covalent structure of human beta-thromboglobulin.. Biochemistry. 1978, 17 (9): 1739–44. PMID 77677. doi:10.1021/bi00602a024.
Kaplan KL, Broekman MJ, Chernoff A; et al. Platelet alpha-granule proteins: studies on release and subcellular localization.. Blood. 1979, 53 (4): 604–18. PMID 426909.
Tunnacliffe A, Majumdar S, Yan B, Poncz M. Genes for beta-thromboglobulin and platelet factor 4 are closely linked and form part of a cluster of related genes on chromosome 4.. Blood. 1992, 79 (11): 2896–900. PMID 1316786.
Cohen AB, Stevens MD, Miller EJ; et al. Generation of the neutrophil-activating peptide-2 by cathepsin G and cathepsin G-treated human platelets.. Am. J. Physiol. 1992, 263 (2 Pt 1): L249–56. PMID 1387511.
Morris SW, Nelson N, Valentine MB; et al. Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35.. Genomics. 1992, 14 (3): 685–91. PMID 1427896. doi:10.1016/S0888-7543(05)80169-7.
Majumdar S, Gonder D, Koutsis B, Poncz M. Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4.. J. Biol. Chem. 1991, 266 (9): 5785–9. PMID 1826003.
Wenger RH, Hameister H, Clemetson KJ. Human platelet basic protein/connective tissue activating peptide-III maps in a gene cluster on chromosome 4q12-q13 along with other genes of the beta-thromboglobulin superfamily.. Hum. Genet. 1991, 87 (3): 367–8. PMID 1830861. doi:10.1007/BF00200921.
Hjemdahl P, Perneby C, Theodorsson E; et al. A new assay for beta-thromboglobulin in urine.. Thromb. Res. 1992, 64 (1): 33–43. PMID 1837963. doi:10.1016/0049-3848(91)90203-9.
Brandt E, Van Damme J, Flad HD. Neutrophils can generate their activator neutrophil-activating peptide 2 by proteolytic cleavage of platelet-derived connective tissue-activating peptide III.. Cytokine. 1991, 3 (4): 311–21. PMID 1873479. doi:10.1016/1043-4666(91)90499-4.
Clark-Lewis I, Moser B, Walz A; et al. Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide.. Biochemistry. 1991, 30 (12): 3128–35. PMID 2007144. doi:10.1021/bi00226a021.
Walz A, Baggiolini M. Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases.. J. Exp. Med. 1990, 171 (2): 449–54. PMC 2187709 . PMID 2406364. doi:10.1084/jem.171.2.449.
Holt JC, Harris ME, Holt AM; et al. Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta-thromboglobulin.. Biochemistry. 1986, 25 (8): 1988–96. PMID 2423119. doi:10.1021/bi00356a023.
Walz A, Baggiolini M. A novel cleavage product of beta-thromboglobulin formed in cultures of stimulated mononuclear cells activates human neutrophils.. Biochem. Biophys. Res. Commun. 1989, 159 (3): 969–75. PMID 2522778. doi:10.1016/0006-291X(89)92203-1.
Wenger RH, Wicki AN, Walz A; et al. Cloning of cDNA coding for connective tissue activating peptide III from a human platelet-derived lambda gt11 expression library.. Blood. 1989, 73 (6): 1498–503. PMID 2713489.
Castor CW, Walz DA, Ragsdale CG; et al. Connective tissue activation. XXXIII. Biologically active cleavage products of CTAP-III from human platelets.. Biochem. Biophys. Res. Commun. 1989, 163 (2): 1071–8. PMID 2783111. doi:10.1016/0006-291X(89)92330-9.
Holt JC, Rabellino EM, Gewirtz AM; et al. Occurrence of platelet basic protein, a precursor of low affinity platelet factor 4 and beta-thromboglobulin, in human platelets and megakaryocytes.. Exp. Hematol. 1988, 16 (4): 302–6. PMID 2966071.
Castor CW, Furlong AM, Carter-Su C. Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III.. Biochemistry. 1985, 24 (7): 1762–7. PMID 4005226. doi:10.1021/bi00328a029.
McLaren KM, Pepper DS. Immunological localisation of beta-thromboglobulin and platelet factor 4 in human megakaryocytes and platelets.. J. Clin. Pathol. 1983, 35 (11): 1227–31. PMC 497932 . PMID 6183294. doi:10.1136/jcp.35.11.1227.
Castor CW, Miller JW, Walz DA. Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor.. Proc. Natl. Acad. Sci. U.S.A. 1983, 80 (3): 765–9. PMC 393460 . PMID 6572368. doi:10.1073/pnas.80.3.765.
Malkowski MG, Wu JY, Lazar JB; et al. The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution.. J. Biol. Chem. 1995, 270 (13): 7077–87. PMID 7706245. doi:10.1074/jbc.270.13.7077.

[entrez-1] Entrez Gene: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7). （原始内容存档于2019-09-24）.

[2] Hristov M, Zernecke A, Bidzhekov K; et al. Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury. Circ. Res. March 2007, 100 (4): 590–7. PMID 17272812. doi:10.1161/01.RES.0000259043.42571.68.

[3] Majumdar S, Gonder D, Koutsis B, Poncz M. Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4. J Biol Chem. 1991, 266 (9): 5785–9. PMID 1826003.

[4] Castor C, Miller J, Walz D. Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor. Proc Natl Acad Sci USA. 1983, 80 (3): 765–9. PMC 393460 . PMID 6572368. doi:10.1073/pnas.80.3.765.

[5] Castor C, Furlong A, Carter-Su C. Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III. Biochemistry. 1985, 24 (7): 1762–7. PMID 4005226. doi:10.1021/bi00328a029.

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