Lin-4
lin-4 microRNA precursor | |
---|---|
預測的lin-4二級結構和保守序列 | |
識別符 | |
代號 | lin-4 |
Rfam | RF00052 |
miRBase | MI0000002 |
miRBase | MIPF0000303 |
其他數據 | |
RNA類型 | Gene; miRNA |
域 | Eukaryota |
lin-4是最早發現的microRNA[1],1993年由維克托·安布羅斯等人在模式生物秀麗隱桿線蟲的基因組中發現[2],轉錄形成70鹼基的前體後由Dicer酶切割形成21鹼基的產物[3]。
參考文獻
- ^ Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.. Cell. 1993, 75 (5): 843–854. PMID 8252621. doi:10.1016/0092-8674(93)90529-Y .
- ^ Ambros, V. microRNAs: tiny regulators with great potential. Cell. 2001, 107 (7): 823–826. PMID 11779458. doi:10.1016/S0092-8674(01)00616-X .
- ^ Rougvie, AE. Control of developmental timing in animals. Nat Rev Genet. 2001, 2 (9): 690–701. PMID 11533718. doi:10.1038/35088566.