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1-乙炔基環己醇

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1-乙炔基環己醇
識別
CAS號 78-27-3  checkY
SMILES
 
  • C#Cc1(O)ccccc1
性質
化學式 C8H12O
摩爾質量 124.18 g·mol−1
密度 0.9809 g·cm−3(20 °C)[1]
熔點 30 °C(303 K)[2]
31—32 °C(304—305 K)[3]
沸點 179 °C(452 K)[3]
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。

1-乙炔基環己醇是一種有機化合物,化學式為C8H12O,它可由乙炔環己酮氫氧化鉀的存在下於DMSO中反應製得。[4]它和乙酸酐反應,生成乙酸-1-乙炔基環己酯。[5]它和有機疊氮化物反應,乙炔基轉化為三唑。[6]

參考文獻

  1. ^ Levina, R. Ya.; Vinogradova, E. I. Action of sodium acetylide on cyclic ketones. I. Synthesis of 1-ethynylcyclohexanol. Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1936. 9: 1299-1302. ISSN: 0044-4618.
  2. ^ Verkruijsse, Hermann D.; Graaf, Wim de; Brandsma, Lambert. An Efficient and Quick Laboratory Scale Method for the Ethynylation of Some Aliphatic and Cycloaliphatic Carbonyl Compounds. Synthetic Communications. 1988, 18 (2): 131–134. ISSN 0039-7911. doi:10.1080/00397918808077336. 
  3. ^ 3.0 3.1 Nazarov, I. N.; Kotlyarevskii, I. L.; Ryabchenko, V. F. Acetylene derivatives. CLX. Condensation of aldehydes and ketones with acetylene under pressure. New method of synthesis of acetylenic alcohols. Zhurnal Obshchei Khimii, 1953. 23: 1900-1904. ISSN: 0044-460X.
  4. ^ Trofimov, B. A.; Sobenina, L. N.; Korostova, S. E.; Mikhaleva, A. I.; Shishov, N. I.; Fel'dman, V. D.; Shevchenko, S. G.; Vasil'ev, A. N. Synthesis of tertiary acetylenic alcohols and their ethers in a potassium hydroxide-dimethyl sulfoxide system. Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1987. 60 (6): 1366-1370. ISSN: 0044-4618.
  5. ^ D'Elia, Valerio; Liu, Yinghao; Zipse, Hendrik. Immobilized DMAP Derivatives Rivaling Homogeneous DMAP. European Journal of Organic Chemistry. 2011, 2011 (8): 1527–1533. ISSN 1434-193X. doi:10.1002/ejoc.201001507. 
  6. ^ Heriberto Díaz Velázquez, Yara Ruiz García, Matthias Vandichel, Annemieke Madder, Francis Verpoort. Water-soluble NHC-Cu catalysts: applications in click chemistry, bioconjugation and mechanistic analysis. Org. Biomol. Chem. 2014, 12 (46): 9350–9356 [2020-08-31]. ISSN 1477-0520. doi:10.1039/C4OB01350F (英語).