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鯊烯-藿烯環化酶

維基百科,自由的百科全書
Squalene-hopene cyclase
鯊烯-藿烯環化酶二聚體的晶體結構
識別碼
EC編號 or 4/2/1/129.html 5.4.99.17
CAS號 76600-69-6
數據庫
IntEnz IntEnz瀏覽
BRENDA英語BRENDA BRENDA入口
ExPASy英語ExPASy NiceZyme瀏覽
KEGG KEGG入口
MetaCyc英語MetaCyc 代謝路徑
PRIAM英語PRIAM_enzyme-specific_profiles 概述
PDB RCSB PDB PDBj PDBe PDBsum

鯊烯-藿烯環化酶(英語:Squalene-hopene cyclase,縮寫SHCEC 5.4.99.17)或稱作藿烷-22-醇水裂解酶(hopan-22-ol hydro-lyase,EC 4.2.1.129)屬於原核生物中生成五環三萜的環化/變位酶家族,能催化下列兩種反應,生成藿烯藿烷-22-醇,兩種產物的比例為5比1[1][2][3][4][5]

鯊烯 22(29)-藿烯
鯊烯 + H2O 藿烷-22-醇


參考文獻

  1. ^ Hoshino T, Sato T. Squalene-hopene cyclase: catalytic mechanism and substrate recognition. Chemical Communications. February 2002,   (4): 291–301. PMID 12120044. doi:10.1039/b108995c. 
  2. ^ Hoshino T, Nakano S, Kondo T, Sato T, Miyoshi A. Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring. Organic & Biomolecular Chemistry. May 2004, 2 (10): 1456–70. PMID 15136801. doi:10.1039/b401172d. 
  3. ^ Sato T, Kouda M, Hoshino T. Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius. Bioscience, Biotechnology, and Biochemistry. March 2004, 68 (3): 728–38. PMID 15056909. doi:10.1271/bbb.68.728. 
  4. ^ Reinert DJ, Balliano G, Schulz GE. Conversion of squalene to the pentacarbocyclic hopene. Chemistry & Biology. January 2004, 11 (1): 121–6. PMID 15113001. doi:10.1016/j.chembiol.2003.12.013. 
  5. ^ Pearson A, Budin M, Brocks JJ. Phylogenetic and biochemical evidence for sterol synthesis in the bacterium Gemmata obscuriglobus. Proceedings of the National Academy of Sciences of the United States of America. December 2003, 100 (26): 15352–7. PMC 307571可免費查閱. PMID 14660793. doi:10.1073/pnas.2536559100. 

外部連結