依普羅醇
依普羅醇 | |
---|---|
![]() | |
IUPAC名 3-[4-(2-Methoxy-2-phenylethyl)piperazin-1-yl]-1-phenylpropan-1-ol | |
識別 | |
CAS號 | 32665-36-4 ![]() |
PubChem | 122553 |
ChemSpider | 109268 |
SMILES |
|
KEGG | D07379 |
性質 | |
化學式 | C22H30N2O2 |
摩爾質量 | 354.4858 g·mol⁻¹ |
藥理學 | |
ATC代碼 | R03DX02(R03) |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
依普羅醇(英語:Eprozinol)是一種含氮有機化合物,化學式C22H30N2O2,能作為阻塞性肺病的藥物[1][2]。
合成
(-)-(R,S)-依普羅醇可由2-氯苯乙酮、N-苄基哌嗪和(S)-3-氯-1-苯基-1-丙醇為原料,經多步反應製得。[3]
參考文獻
- ^ Nicrosini, F.; Carpinella, G. Eprozinol treatment of chronic bronchitis with dyspnea and cough. Broncho-pneumologie. 1978, 28 (4): 322–327. PMID 756799.
- ^ Labrid, C.; Duchene-Marullaz, P.; Rispat, G. Mechanisms of anti-bronchoconstrictive effects of eprozinol. II. In vivo studies on the guinea pig. Pharmacology. 1981, 23 (1): 48–55. PMID 7312935. doi:10.1159/000137526.
- ^ P. Veeraraghavan Ramachandran, Baoqing Gong, Herbert C. Brown. Chiral synthesis via organoboranes. 41. The utility of B-chlorodiisopinocampheylborane for a general synthesis of enantiomerically pure drugs. Chirality. 1995. 7 (2). 103-110. doi:10.1002/chir.530070209.
外部連結
|