BxPC-3細胞

BxPC-3 (BxPC3）是用於研究胰腺癌及其治療方法的人類胰腺癌細胞系。BxPC-3細胞是在1986年從一個已61歲的人類女性體內獲得，並且被證實在無胸腺裸鼠中具有致瘤性，具有中等分化能力^[1]，同時又會產生粘蛋白，並且表現出上皮組織形態。BxPC-3細胞不會發生在胰腺癌中常見的KRAS（英語：KRAS）突變^[2]。BcPC-3細胞和JoPaca-1細胞均有高表達的癌幹細胞標誌物（英語：Stem cell marker）^[3]。BxPC-3目前已用於致瘤研究、胰腺癌治療研究及其他生物醫學應用中。由於細胞可幫助胰腺癌藥物的開發，因此有學者對細胞的表型和基因型特性進行研究，特別是因為BxPC-3細胞具有血管生成因子IL-8、血管內皮生長因子和前列腺素E2的高度表達，故而可以作為潛在的藥物靶標^[4]。

參考資料

^ Tan, MH; Nowak, NJ; Loor, R; Ochi, H; Sandberg, AA; Lopez, C; Pickren, JW; Berjian, R; Douglass HO, Jr; Chu, TM. Characterization of a new primary human pancreatic tumor line.. Cancer investigation. 1986, 4 (1): 15–23 [2019-11-25]. PMID 3754176. doi:10.3109/07357908609039823.
^ Berrozpe, G; Schaeffer, J; Peinado, MA; Real, FX; Perucho, M. Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer.. International journal of cancer. 1994-07-15, 58 (2): 185–91 [2019-11-25]. PMID 8026879. doi:10.1002/ijc.2910580207.
^ Fredebohm, J; Boettcher, M; Eisen, C; Gaida, MM; Heller, A; Keleg, S; Tost, J; Greulich-Bode, KM; Hotz-Wagenblatt, A; Lathrop, M; Giese, NA; Hoheisel, JD. Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system.. PloS one. 2012, 7 (11): e48503 [2019-11-25]. PMID 23152778. doi:10.1371/journal.pone.0048503.
^ Deer, EL; González-Hernández, J; Coursen, JD; Shea, JE; Ngatia, J; Scaife, CL; Firpo, MA; Mulvihill, SJ. Phenotype and genotype of pancreatic cancer cell lines.. Pancreas. 2010-05, 39 (4): 425–35 [2019-11-25]. PMID 20418756. doi:10.1097/MPA.0b013e3181c15963.

[1] Tan, MH; Nowak, NJ; Loor, R; Ochi, H; Sandberg, AA; Lopez, C; Pickren, JW; Berjian, R; Douglass HO, Jr; Chu, TM. Characterization of a new primary human pancreatic tumor line.. Cancer investigation. 1986, 4 (1): 15–23 [2019-11-25]. PMID 3754176. doi:10.3109/07357908609039823.

[2] Berrozpe, G; Schaeffer, J; Peinado, MA; Real, FX; Perucho, M. Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer.. International journal of cancer. 1994-07-15, 58 (2): 185–91 [2019-11-25]. PMID 8026879. doi:10.1002/ijc.2910580207.

[3] Fredebohm, J; Boettcher, M; Eisen, C; Gaida, MM; Heller, A; Keleg, S; Tost, J; Greulich-Bode, KM; Hotz-Wagenblatt, A; Lathrop, M; Giese, NA; Hoheisel, JD. Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system.. PloS one. 2012, 7 (11): e48503 [2019-11-25]. PMID 23152778. doi:10.1371/journal.pone.0048503.

[4] Deer, EL; González-Hernández, J; Coursen, JD; Shea, JE; Ngatia, J; Scaife, CL; Firpo, MA; Mulvihill, SJ. Phenotype and genotype of pancreatic cancer cell lines.. Pancreas. 2010-05, 39 (4): 425–35 [2019-11-25]. PMID 20418756. doi:10.1097/MPA.0b013e3181c15963.

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