BRL-37344

BRL-37344
臨床資料
商品名（英語：Drug nomenclature）	BRL-37344
法律規範狀態
法律規範	美：Investigational New Drug;
識別資訊
	IUPAC命名法 2-{4-[(2R)-2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}propyl]phenoxy}acetic acid; ;
CAS號	114333-71-0
PubChem CID	9841972;
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID101126185 ;
化學資訊
化學式	C19H22ClNO4
摩爾質量	363.8
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES C[C@H](CC1=CC=C(C=C1)OCC(=O)O)NC[C@@H](C2=CC(=CC=C2)Cl)O;
	InChI InChI=1S/C19H22ClNO4/c1-13(21-11-18(22)15-3-2-4-16(20)10-15)9-14-5-7-17(8-6-14)25-12-19(23)24/h2-8,10,13,18,21-22H,9,11-12H2,1H3,(H,23,24)/t13-,18+/m1/s1; Key:ZGGNJJJYUVRADP-ACJLOTCBSA-N;

BRL-37344是一種藥物，分子式C₁₉H₂₂ClNO₄，為β-3腎上腺素（英語：Beta-3 adrenergic receptor）受體選擇性激動劑，^[1]已針對各種生物醫學的應用開展了相關研究，但尚未提供臨床使用。^[2]^[3]^[4]^[5]^[6]^[7]

參考文獻

^ Bond RA, Clarke DE. Agonist and antagonist characterization of a putative adrenoceptor with distinct pharmacological properties from the alpha- and beta-subtypes. British Journal of Pharmacology. November 1988, 95 (3): 723–34. PMC 1854239 . PMID 2905184. doi:10.1111/j.1476-5381.1988.tb11698.x.
^ Napp A, Brixius K, Pott C, Ziskoven C, Boelck B, Mehlhorn U, et al. Effects of the beta3-adrenergic agonist BRL 37344 on endothelial nitric oxide synthase phosphorylation and force of contraction in human failing myocardium. Journal of Cardiac Failure. February 2009, 15 (1): 57–67. PMID 19181295. doi:10.1016/j.cardfail.2008.08.006.
^ Afeli SA, Rovner ES, Petkov GV. BRL37344, a β3-adrenergic receptor agonist, decreases nerve-evoked contractions in human detrusor smooth muscle isolated strips: role of BK channels. Urology. September 2013, 82 (3): 744.e1–7. PMC 3758792 . PMID 23890664. doi:10.1016/j.urology.2013.05.027.
^ Maryanovich M, Zahalka AH, Pierce H, Pinho S, Nakahara F, Asada N, et al. Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche. Nature Medicine. June 2018, 24 (6): 782–791. PMC 6095812 . PMID 29736022. doi:10.1038/s41591-018-0030-x.
^ Xu Z, Wu J, Xin J, Feng Y, Hu G, Shen J, et al. β3-adrenergic receptor activation induces TGFβ1 expression in cardiomyocytes via the PKG/JNK/c-Jun pathway. Biochemical and Biophysical Research Communications. September 2018, 503 (1): 146–151. PMID 29859189. doi:10.1016/j.bbrc.2018.05.200.
^ Grzelka K, Gawlak M, Czarzasta K, Szulczyk P. β3-adrenergic receptor stimulation on the resting holding current of medial prefrontal cortex pyramidal neurons in young rats. Neuroscience Letters. April 2019, 698: 192–197. PMID 30641111. doi:10.1016/j.neulet.2019.01.022.
^ Fellous TG, Redpath AN, Fleischer MM et al. Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery. npj Regen Med 2020; 5: 3. doi:10.1038/s41536-020-0088-1

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[1] Bond RA, Clarke DE. Agonist and antagonist characterization of a putative adrenoceptor with distinct pharmacological properties from the alpha- and beta-subtypes. British Journal of Pharmacology. November 1988, 95 (3): 723–34. PMC 1854239 . PMID 2905184. doi:10.1111/j.1476-5381.1988.tb11698.x.

[2] Napp A, Brixius K, Pott C, Ziskoven C, Boelck B, Mehlhorn U, et al. Effects of the beta3-adrenergic agonist BRL 37344 on endothelial nitric oxide synthase phosphorylation and force of contraction in human failing myocardium. Journal of Cardiac Failure. February 2009, 15 (1): 57–67. PMID 19181295. doi:10.1016/j.cardfail.2008.08.006.

[3] Afeli SA, Rovner ES, Petkov GV. BRL37344, a β3-adrenergic receptor agonist, decreases nerve-evoked contractions in human detrusor smooth muscle isolated strips: role of BK channels. Urology. September 2013, 82 (3): 744.e1–7. PMC 3758792 . PMID 23890664. doi:10.1016/j.urology.2013.05.027.

[4] Maryanovich M, Zahalka AH, Pierce H, Pinho S, Nakahara F, Asada N, et al. Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche. Nature Medicine. June 2018, 24 (6): 782–791. PMC 6095812 . PMID 29736022. doi:10.1038/s41591-018-0030-x.

[5] Xu Z, Wu J, Xin J, Feng Y, Hu G, Shen J, et al. β3-adrenergic receptor activation induces TGFβ1 expression in cardiomyocytes via the PKG/JNK/c-Jun pathway. Biochemical and Biophysical Research Communications. September 2018, 503 (1): 146–151. PMID 29859189. doi:10.1016/j.bbrc.2018.05.200.

[6] Grzelka K, Gawlak M, Czarzasta K, Szulczyk P. β3-adrenergic receptor stimulation on the resting holding current of medial prefrontal cortex pyramidal neurons in young rats. Neuroscience Letters. April 2019, 698: 192–197. PMID 30641111. doi:10.1016/j.neulet.2019.01.022.

[7] Fellous TG, Redpath AN, Fleischer MM et al. Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery. npj Regen Med 2020; 5: 3. doi:10.1038/s41536-020-0088-1

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