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5-氟二甲基色胺

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5-氟二甲基色胺
識別資訊
  • 2-(5-fluoro-1H-indol-3-yl)-N,N-dimethylethanamine
CAS號22120-36-1  checkY
PubChem CID
ChemSpider
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
化學資訊
化學式C12H15FN2
摩爾質量206.26 g·mol−1
3D模型(JSmol英語JSmol
  • CN(C)CCC1=CNC2=C1C=C(C=C2)F
  • InChI=1S/C12H15FN2/c1-15(2)6-5-9-8-14-12-4-3-10(13)7-11(9)12/h3-4,7-8,14H,5-6H2,1-2H3 checkY
  • Key:BXYDWQABVPBLBU-UHFFFAOYSA-N checkY

5-氟-N,N-二甲基色胺(英語:5-Fluoro-N,N-dimethyltryptamine,簡稱5-fluoro-DMT,5-氟二甲基色胺)是一種色胺衍生物,類似於5-溴二甲基色胺5-甲氧基二甲基色胺。二甲基色胺的氟取代對其與5-HT2A/C受體的親和性影響不大,但6-氟二乙基色胺對5-HT2A受體的激動性幾乎無效,而4-氟-5-甲基二甲基色胺卻是5-HT1A受體的強激動劑[1][2]

參考文獻

  1. ^ Blair, JB; Kurrasch-Orbaugh, D; Marona-Lewicka, D; Cumbay, MG; Watts, VJ; Barker, EL; Nichols, DE. Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines. Journal of Medicinal Chemistry. 2000, 43 (24): 4701–10. PMID 11101361. doi:10.1021/jm000339w. 
  2. ^ Rabin, RA; Regina, M; Doat, M; Winter, JC. 5-HT2A receptor-stimulated phosphoinositide hydrolysis in the stimulus effects of hallucinogens. Pharmacology, Biochemistry, and Behavior. 2002, 72 (1–2): 29–37. PMID 11900766. doi:10.1016/S0091-3057(01)00720-1. 

外部連結