高良薑素
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高良姜素 | |
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IUPAC名 3,5,7-Trihydroxy-2-phenylchromen-4-one | |
英文名 | Galangin |
別名 | 3,5,7-三羥基黃酮 |
識別 | |
CAS號 | 548-83-4 ![]() |
PubChem | 5281616 |
ChemSpider | 4444935 |
SMILES |
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InChI |
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InChIKey | VCCRNZQBSJXYJD-UHFFFAOYAC |
ChEBI | 5262 |
KEGG | C10044 |
IUPHAR配體 | 410 |
性質 | |
化學式 | C15H10O5 |
摩爾質量 | 270.24 g·mol−1 |
密度 | 1.579 g/mL |
熔點 | 214-215 °C(487-488 K) |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
高良姜素(化學式C15H10O5)是一種黃酮醇。
來源
植物高良姜[1]和蠟菊中含有大量的高良姜素。[2]除此之外,高良姜素還見於大高良姜的根莖[3]和蜂膠中。[4]
生物活性
研究發現,高良姜素在體外具有抗菌[5][6]和抗病毒活性。[7]同時,體外試驗還發現高良姜素能抑制乳腺癌細胞的增殖。[8][9]
參考資料
- ^ Ciolino, H. P.; Yeh, G. C. The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor. British Journal of Cancer. 1999, 79 (9/10): 1340–1346. PMC 2362711
. PMID 10188874. doi:10.1038/sj.bjc.6690216.
- ^ Afolayan AJ, Meyer JJ. The antimicrobial activity of 3,5,7-trihydroxyflavone isolated from the shoots of Helichrysum aureonitens. Journal of Ethnopharmacology. 1997, 57 (3): 177–181. PMID 9292410. doi:10.1016/s0378-8741(97)00065-2.
- ^ Kaur, A.; Singh, R.; Dey, C. S.; Sharma, S. S.; Bhutani, K. K.; Singh, I. P. Antileishmanial phenylpropanoids from Alpinia galanga (Linn.) Willd (PDF). Indian Journal of Experimental Biology. 2010, 48 (3): 314–317 [2021-04-10]. PMID 21046987. (原始內容存檔 (PDF)於2020-01-25).
- ^ Tosi, E; Re, E; Ortega, M; Cazzoli, A. Food preservative based on propolis: Bacteriostatic activity of propolis polyphenols and flavonoids upon Escherichia coli. Food Chemistry. 2007, 104: 1025. doi:10.1016/j.foodchem.2007.01.011.
- ^ Cushnie TP, Lamb AJ. Assessment of the antibacterial activity of galangin against 4-quinolone resistant strains of Staphylococcus aureus. Phytomedicine. 2006, 13 (3): 187–191. PMID 16428027. doi:10.1016/j.phymed.2004.07.003.
- ^ Cushnie TP, Lamb AJ. Detection of galangin-induced cytoplasmic membrane damage in Staphylococcus aureus by measuring potassium loss. Journal of Ethnopharmacology. 2005, 101 (1–3): 243–248. PMID 15985350. doi:10.1016/j.jep.2005.04.014.
- ^ Afolayan AJ, Meyer JJ, Taylor MB, Erasmus D. Antiviral activity of galangin isolated from the aerial parts of Helichrysum aureonitens. Journal of Ethnopharmacology. 1997, 56 (2): 165–169. PMID 917497. doi:10.1016/s0378-8741(97)01514-6.
- ^ So, F. V.; Guthrie, N.; Chambers, A. F.; Moussa, M.; Carroll, K. K. Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutrition and Cancer. 1996, 26 (2): 167–181. PMID 8875554. doi:10.1080/01635589609514473.
- ^ So, F.; Guthrie, N.; Chambers, A. F.; Carroll, K. K. Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen. Cancer Letters. 1997, 112 (2): 127–133. PMID 9066718. doi:10.1016/S0304-3835(96)04557-0.
外部連結
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