森沙夫定 |
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其他名称 | 4'-ethynylstavudine, festinavir |
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法律规范 |
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1-[(2R,5R)-5-ethynyl-5-(hydroxymethyl)-2H-furan-2-yl]-5-methylpyrimidine-2,4-dione
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CAS号 | 634907-30-5 |
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PubChem CID | |
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ChemSpider | |
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UNII | |
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KEGG | |
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ChEMBL | |
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NIAID ChemDB | |
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CompTox Dashboard (EPA) | |
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ECHA InfoCard | 100.225.812 |
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化学式 | C12H12N2O4 |
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摩尔质量 | 248.24 g·mol−1 |
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3D模型(JSmol) | |
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CC1=CN(C(=O)NC1=O)[C@H]2C=C[C@](O2)(CO)C#C
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InChI=1S/C12H12N2O4/c1-3-12(7-15)5-4-9(18-12)14-6-8(2)10(16)13-11(14)17/h1,4-6,9,15H,7H2,2H3,(H,13,16,17)/t9-,12+/m1/s1 Key:OSYWBJSVKUFFSU-SKDRFNHKSA-N
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森沙夫定(英语:Censavudine,开发代码:BMS-986001,也称为4'-乙炔基司他夫定,4'-ethynylstavudine)是一种含氮有机化合物,化学式为C12H12N2O4,由百时美施贵宝作为HIV抑制剂开发。[1][2]
参考文献
- ^ Wu VH, Smith RA, Masoum S, Raugi DN, Ba S, Seydi M, et al. MK-8591 (4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine) Exhibits Potent Activity against HIV-2 Isolates and Drug-Resistant HIV-2 Mutants in Culture. Antimicrobial Agents and Chemotherapy. August 2017, 61 (8). PMC 5527656 . PMID 28559249. doi:10.1128/AAC.00744-17.
- ^ Gupta SK, McComsey GA, Lombaard J, Echevarría J, Orrell C, Avihingsanon A, et al. Efficacy, safety, bone and metabolic effects of HIV nucleoside reverse transcriptase inhibitor BMS-986001 (AI467003): a phase 2b randomised, controlled, partly blinded trial. The Lancet. HIV. January 2016, 3 (1): e13–22. PMID 26762988. doi:10.1016/S2352-3018(15)00231-3. hdl:1805/10552 .