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COLO 201

维基百科,自由的百科全书

COLO 201 (亦称ATCC CCL-224) 是对癌胚抗原及结肠抗原呈阴性角蛋白波形纤维蛋白呈弱阳性的人类结肠癌细胞系[1],呈成纤维细胞样,最初于1957年分离自一名70岁的白人男性结肠癌患者腹水,该患者已接受5-氟尿嘧啶治疗数周[2]。有研究指出COLO 201的标记染色体英语Marker chromosomeCOLO 205相同,并且发现在COLO 201及COLO 205细胞中出现的等臂染色体英语Isochromosome5在COLO 206细胞中不存在[2]。目前应用于细胞毒性测定和免疫球蛋白表征的免疫学研究[2]

参考资料

  1. ^ Björk, P; Jönsson, U; Svedberg, H; Larsson, K; Lind, P; Dillner, J; Hedlund, G; Dohlsten, M; Kalland, T. Isolation, partial characterization, and molecular cloning of a human colon adenocarcinoma cell-surface glycoprotein recognized by the C215 mouse monoclonal antibody.. The Journal of biological chemistry. 1993-11-15, 268 (32): 24232–41 [2019-12-09]. PMID 7693697. 
  2. ^ 2.0 2.1 2.2 Semple, TU; Quinn, LA; Woods, LK; Moore, GE. Tumor and lymphoid cell lines from a patient with carcinoma of the colon for a cytotoxicity model.. Cancer research. 1978-05, 38 (5): 1345–55 [2019-12-09]. PMID 565251. 

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