降钙素 (英语:calcitonin )又称降钙激素 、抑钙素 [ 2] ,是一种含有32个氨基酸 的直线型多肽 类激素 ,在人体里是由甲状腺 的滤泡旁细胞 (parafollicular cells,又称C细胞)制造。在鱼类 、爬虫类 、鸟类 、哺乳类 身上都有发现这种激素。降钙素主要功能是降低血钙,但其对于调节人体血液中钙离子 的恒定通常并没有很显著的重要性。[ 3]
主要作用
降钙素影响了钙离子和磷酸盐的代谢过程,其功能多半是拮抗副甲状腺素 的作用。[ 4]
降钙素主要透过下列四种方式降低血钙浓度:
抑制小肠 对于钙离子的吸收。[ 5]
抑制蚀骨细胞 ,减少骨骼中的钙离子流失到血液中。[ 6]
抑制肾小管 对磷酸根的再吸收 作用。[ 7]
抑制肾小管 对钙离子的再吸收作用,增加钙离子自尿液 流失。[ 7]
分泌
刺激降钙素分泌的因素:
参考资料
^ PDB 2glh Andreotti G, Méndez BL, Amodeo P, Morelli MA, Nakamuta H, Motta A. Structural determinants of salmon calcitonin bioactivity: the role of the Leu-based amphipathic alpha-helix. J. Biol. Chem. August 2006, 281 (34): 24193–203. PMID 16766525 . doi:10.1074/jbc.M603528200 .
^ 存档副本 . [2022-11-27 ] . (原始内容存档 于2022-11-27).
^ Costoff A. Sect. 5, Ch. 6: Biological Actions of CT . Medical College of Georgia. [2008-08-07 ] . (原始内容 存档于2008-07-05).
^ Boron WF, Boulpaep EL. Endocrine system chapter. Medical Physiology: A Cellular And Molecular Approach . Elsevier/Saunders. 2004. ISBN 1-4160-2328-3 .
^ Costoff A. Sect. 5, Ch. 6: Effects of CT on the Small Intestine . Medical College of Georgia. [2008-08-07 ] . (原始内容 存档于2008-10-06).
^ Costoff A. Sect. 5, Ch. 6: Effects of CT on Bone . Medical College of Georgia. [2008-08-07 ] . (原始内容 存档于2008-06-22).
^ 7.0 7.1 Carney SL. Calcitonin and human renal calcium and electrolyte transport. Miner Electrolyte Metab. 1997, 23 (1): 43–7. PMID 9058369 .
^ Costanzo, Linda S. BRS Physiology . Lippincott, Williams, & Wilkins. 2007: 263 [2010-10-23 ] . ISBN 978-0781773119 . (原始内容存档 于2010-09-25).
^ Erdogan MF, Gursoy A, Kulaksizoglu M. Long-term effects of elevated gastrin levels on calcitonin secretion . J Endocrinol Invest. October 2006, 29 (9): 771–775. PMID 17114906 . (原始内容 存档于2016-05-15).
延伸阅读
MacIntyre I, Alevizaki M, Bevis PJ, Zaidi M. Calcitonin and the peptides from the calcitonin gene . Clinical Orthopaedics and Related Research. April 1987, (217): 45–55. PMID 3549095 . doi:10.1097/00003086-198704000-00007 .
Di Angelantonio S, Giniatullin R, Costa V, Sokolova E, Nistri A. Modulation of neuronal nicotinic receptor function by the neuropeptides CGRP and substance P on autonomic nerve cells . British Journal of Pharmacology. July 2003, 139 (6): 1061–73. PMC 1573932 . PMID 12871824 . doi:10.1038/sj.bjp.0705337 .
Findlay DM, Sexton PM. Calcitonin. Growth Factors. December 2004, 22 (4): 217–24. PMID 15621724 . doi:10.1080/08977190410001728033 .
Sponholz C, Sakr Y, Reinhart K, Brunkhorst F. Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery: a systematic review of the literature . Critical Care. 2007, 10 (5): R145. PMC 1751067 . PMID 17038199 . doi:10.1186/cc5067 .
Schneider HG, Lam QT. Procalcitonin for the clinical laboratory: a review. Pathology. August 2007, 39 (4): 383–90. PMID 17676478 . doi:10.1080/00313020701444564 .
Grani G, Nesca A, Del Sordo M, Calvanese A, Carbotta G, Bianchini M, Fumarola A. Interpretation of serum calcitonin in patients with chronic autoimmune thyroiditis. Endocrine-Related Cancer (Bioscientifica ). June 2012, 19 (3): 345–9. PMID 22399011 . doi:10.1530/ERC-12-0013 .
参见
外部链接
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