LHX2

LIM homeobox 2
	蛋白質資料庫依據2dmq給出
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	2dmq
标识
代号	LHX2; LH2; hLhx2
扩展标识	遗传学：603759 鼠基因：96785 同源基因：55848 GeneCards: LHX2 Gene
基因本体论描述
分子功能	· transcription factor activity, RNA polymerase II transcription factor binding; · chromatin binding; · zinc ion binding; · sequence-specific DNA binding;
细胞成分	· nucleus;
生物过程	· neural tube closure; · hair follicle development; · transcription from RNA polymerase II promoter; · axon guidance; · mesoderm development; · dorsal/ventral pattern formation; · olfactory bulb development; · telencephalon regionalization; · cerebral cortex development; · maintenance of epithelial cell apical/basal polarity; · positive regulation of transcription, DNA-templated; · positive regulation of transcription from RNA polymerase II promoter; · axon extension; · retina development in camera-type eye; · negative regulation of transcription regulatory region DNA binding;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
	查; 论; 编;

LIM同源框蛋白質 LHX2是蛋白質的一種，在人類內由「LHX2」基因所編碼。^[1]^[2]^[3]

LHX2包含LIM結構域，这是一種帶有許多半胱氨酸，具鋅指結構的結構域。該蛋白質的作用為轉錄調控。該蛋白質在果蠅體內，可用來回復由其他蛋白質引起的表型，推測是在演化時留下的功能^[3]。

交互作用

LHX2已證實會與CITED2 交互作用。^[4]

^ Wu HK, Heng HH, Siderovski DP, Dong WF, Okuno Y, Shi XM, Tsui LC, Minden MD. Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1. Oncogene. Jul 1996, 12 (6): 1205–12. PMID 8649822.
^ Rincon-Limas DE, Lu CH, Canal I, Calleja M, Rodriguez-Esteban C, Izpisua-Belmonte JC, Botas J. Conservation of the expression and function of apterous orthologs in Drosophila and mammals. Proc Natl Acad Sci U S A. Apr 1999, 96 (5): 2165–70. PMC 26754 . PMID 10051612. doi:10.1073/pnas.96.5.2165.
^ ^3.0 ^3.1 Entrez Gene: LHX2 LIM homeobox 2.
^ Glenn, D J; Maurer R A. MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. J. Biol. Chem. (UNITED STATES). Dec 1999, 274 (51): 36159–67. ISSN 0021-9258. PMID 10593900. doi:10.1074/jbc.274.51.36159.

Gerhard DS, Wagner L, Feingold EA et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Ota T, Suzuki Y, Nishikawa T et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Strausberg RL, Feingold EA, Grouse LH et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Glenn DJ, Maurer RA. MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. J. Biol. Chem. 2000, 274 (51): 36159–67. PMID 10593900. doi:10.1074/jbc.274.51.36159.
Bach I, Rodriguez-Esteban C, Carrière C et al. RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat. Genet. 1999, 22 (4): 394–9. PMID 10431247. doi:10.1038/11970.
Bendall AJ, Rincón-Limas DE, Botas J, Abate-Shen C. Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity. Differentiation. 1998, 63 (3): 151–7. PMID 9697309. doi:10.1046/j.1432-0436.1998.6330151.x.