B4GALT5
| UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 尿苷二磷酸半乳糖β，N-乙酰葡萄糖胺β1,4-半乳糖基转移酶，多肽5 | |||
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| 标识 | |||
| 代号 | B4GALT5; B4Gal-T5; BETA4-GALT-IV; beta4Gal-T5; beta4GalT-V; gt-V | ||
| 扩展标识 | 遗传学：604016 鼠基因：1927169 同源基因：3507 GeneCards: B4GALT5 Gene | ||
| EC編號 | 2.4.1.38 | ||
| RNA表达模式 | |||
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| 更多表达数据 | |||
| 直系同源体 | |||
| 物种 | 人类 | 小鼠 | |
| Entrez | 9334 | 56336 | |
| Ensembl | ENSG00000158470 | ENSMUSG00000017929 | |
| UniProt | O43286 | Q9JMK0 | |
| mRNA序列 | NM_004776 | NM_019835 | |
| 蛋白序列 | NP_004767 | NP_062809 | |
| 基因位置 |
Chr 20: 48.25 – 48.33 Mb |
Chr 2: 167.3 – 167.35 Mb | |
| PubMed查询 | [1] | [2] | |
β-1,4-半乳糖基转移酶5（英語：Beta-1,4-galactosyltransferase 5）是一种由人类基因B4GALT5 所表达的酶[1][2][3]。
参考文献
- ^ Lo NW, Shaper JH, Pevsner J, Shaper NL. The expanding beta 4-galactosyltransferase gene family: messages from the databanks. Glycobiology. Aug 1998, 8 (5): 517–26. PMID 9597550. doi:10.1093/glycob/8.5.517.
- ^ Sato T, Furukawa K, Bakker H, Van den Eijnden DH, Van Die I. Molecular cloning of a human cDNA encoding β-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc β-1,4-galactosyltransferase. Proc Natl Acad Sci U S A. Feb 1998, 95 (2): 472–7. PMC 18444
. PMID 9435216. doi:10.1073/pnas.95.2.472.
- ^ Entrez Gene: B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5.
延伸阅读
- Amado M, Almeida R, Schwientek T, Clausen H. Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. Biochim. Biophys. Acta. 2000, 1473 (1): 35–53. PMID 10580128. doi:10.1016/S0304-4165(99)00168-3.
- Sato T, Aoki N, Matsuda T, Furukawa K. Differential effect of alpha-lactalbumin on beta-1,4-galactosyltransferase IV activities. Biochem. Biophys. Res. Commun. 1998, 244 (3): 637–41. PMID 9535717. doi:10.1006/bbrc.1998.8327.
- Deloukas P, Matthews LH, Ashurst J; et al. The DNA sequence and comparative analysis of human chromosome 20. Nature. 2002, 414 (6866): 865–71. PMID 11780052. doi:10.1038/414865a.
- Jia L, Young MF, Powell J; et al. Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis. Genomics. 2002, 79 (1): 7–17. PMID 11827452. doi:10.1006/geno.2001.6683.
- Xu S, Zhang S, Chen C; et al. Over-expression of beta-1,4-galactosyltransferase V increases the growth of astrocytoma cell line. J. Exp. Clin. Cancer Res. 2003, 21 (3): 409–14. PMID 12385586.
- Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Ota T, Suzuki Y, Nishikawa T; et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Sato T, Furukawa K. Transcriptional regulation of the human beta-1,4-galactosyltransferase V gene in cancer cells: essential role of transcription factor Sp1. J. Biol. Chem. 2004, 279 (38): 39574–83. PMID 15263012. doi:10.1074/jbc.M405805200.
- Gerhard DS, Wagner L, Feingold EA; et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Jiang J, Chen X, Shen J; et al. Beta1,4-galactosyltransferase V functions as a positive growth regulator in glioma. J. Biol. Chem. 2006, 281 (14): 9482–9. PMID 16461357. doi:10.1074/jbc.M504489200.
- Sato T, Furukawa K. Sequential action of Ets-1 and Sp1 in the activation of the human beta-1,4-galactosyltransferase V gene involved in abnormal glycosylation characteristic of cancer cells. J. Biol. Chem. 2007, 282 (38): 27702–12. PMID 17656364. doi:10.1074/jbc.M611862200.
- Kitayama K, Hayashida Y, Nishida K, Akama TO. Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans. J. Biol. Chem. 2007, 282 (41): 30085–96. PMID 17690104. doi:10.1074/jbc.M703695200.