8,9-脱氢雌酮

**8,9-脱氢雌酮**
臨床資料
其他名稱	Δ8-Estrone; Estra-1,3,5(10),8-tetraen-3-ol-17-one
给药途径	By mouth
藥物類別（英语：Drug class）	Estrogen
识别信息
	IUPAC命名法 (13S,14S)-3-Hydroxy-13-methyl-7,11,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-one; ;
CAS号	474-87-3
PubChem CID	6451472;
ChemSpider	4953937;
UNII	7C1N8RKG9F;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID40197125 ;
化学信息
化学式	C18H20O2
摩尔质量	268.36 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES C[C@]12CCC3=C([C@@H]1CCC2=O)CCC4=C3C=CC(=C4)O;
	InChI InChI=1S/C18H20O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,16,19H,2,4,6-9H2,1H3/t16-,18-/m0/s1; Key:OUGSRCWSHMWPQE-WMZOPIPTSA-N;

8,9-脱氢雌酮（英語：8,9-Dehydroestrone，Δ⁸-estrone）也称为异马烯雌酮（英語：isoequilin）是一种存在于马中的天然雌激素，半系统名：雌甾-1,3,5(10),8-四烯-3-醇-17-酮，estra-1,3,5(10),8-tetraen-3-ol-17-one^[1]。8,9-脱氢雌酮的3-硫酸酯是結合型雌激素（普立马）的成分之一，约占3.5%^[2]。8,9-脱氢雌酮在体内可转化成8,9-脱氢雌二醇，过程类似于雌酮转化成雌二醇^[3]^[4]。

参考文献

^ Baracat E, Haidar M, Lopez FJ, Pickar J, Dey M, Negro-Vilar A. Estrogen activity and novel tissue selectivity of delta8,9-dehydroestrone sulfate in postmenopausal women. J. Clin. Endocrinol. Metab. June 1999, 84 (6): 2020–7. PMID 10372704. doi:10.1210/jcem.84.6.5800 .
^ Marc A. Fritz; Leon Speroff. Clinical Gynecologic Endocrinology and Infertility. Lippincott Williams & Wilkins. 28 March 2012: 751– [2022-02-06]. ISBN 978-1-4511-4847-3. （原始内容存档于2021-05-03）.
^ Bhavnani BR. Pharmacokinetics and pharmacodynamics of conjugated equine estrogens: chemistry and metabolism. Proc. Soc. Exp. Biol. Med. January 1998, 217 (1): 6–16. PMID 9421201. S2CID 45177839. doi:10.3181/00379727-217-44199.
^ Bhavnani BR, Cecutti A, Gerulath A. Pharmacokinetics and pharmacodynamics of a novel estrogen delta8-estrone in postmenopausal women and men. J. Steroid Biochem. Mol. Biol. October 1998, 67 (2): 119–31. PMID 9877212. S2CID 54352249. doi:10.1016/s0960-0760(98)00082-x.

[pmid10372704-1] Baracat E, Haidar M, Lopez FJ, Pickar J, Dey M, Negro-Vilar A. Estrogen activity and novel tissue selectivity of delta8,9-dehydroestrone sulfate in postmenopausal women. J. Clin. Endocrinol. Metab. June 1999, 84 (6): 2020–7. PMID 10372704. doi:10.1210/jcem.84.6.5800 .

[FritzSperoff2012-2] Marc A. Fritz; Leon Speroff. Clinical Gynecologic Endocrinology and Infertility. Lippincott Williams & Wilkins. 28 March 2012: 751– [2022-02-06]. ISBN 978-1-4511-4847-3. （原始内容存档于2021-05-03）.

[pmid9421201-3] Bhavnani BR. Pharmacokinetics and pharmacodynamics of conjugated equine estrogens: chemistry and metabolism. Proc. Soc. Exp. Biol. Med. January 1998, 217 (1): 6–16. PMID 9421201. S2CID 45177839. doi:10.3181/00379727-217-44199.

[pmid9877212-4] Bhavnani BR, Cecutti A, Gerulath A. Pharmacokinetics and pharmacodynamics of a novel estrogen delta8-estrone in postmenopausal women and men. J. Steroid Biochem. Mol. Biol. October 1998, 67 (2): 119–31. PMID 9877212. S2CID 54352249. doi:10.1016/s0960-0760(98)00082-x.

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