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7α-羟基胆固醇

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7α-Hydroxycholesterol
IUPAC名
(3S,7S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol
识别
CAS号 566-26-7  checkY
PubChem 107722
ChemSpider 96891
SMILES
 
  • CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@@H](C=C4[C@@]3(CC[C@@H](C4)O)C)O)C
InChI
 
  • 1/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-25,28-29H,6-15H2,1-5H3/t18-,20+,21-,22+,23+,24-,25+,26+,27-/m1/s1
InChIKey OYXZMSRRJOYLLO-RVOWOUOIBF
MeSH 7+alpha-hydroxycholesterol
IUPHAR配体 4351
性质
化学式 C27H46O2
摩尔质量 402.653 g/mol g·mol⁻¹
熔点 174—176 °C(447—449 K)[1]
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

7α-羟基胆固醇(英語:7α-Hydroxycholesterol)是动物体内合成胆汁酸前体,由胆固醇7α-羟化酶英语cholesterol 7α-hydroxylase(CYP7A1)催化,是胆汁酸合成的限速步驟[2]

参考文献

  1. ^ >Haslewood, G. A. D. Metabolism of steroids. Biochemical Journal. 1941, 35 (5-6): 708–711. ISSN 0306-3283. doi:10.1042/bj0350708. 
  2. ^ Miao J. Regulation of Bile Acid Biosynthesis by Orphan Nuclear Receptor Small Heterodimer Partner (学位论文). University of Illinois at Urbana-Champaign. 2008. [失效連結]