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4α-甲基粪生甾醇

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4α-甲基粪生甾醇
识别
CAS号 17757-07-2
PubChem 193524
ChemSpider 167937
SMILES
 
  • C[C@H]1[C@@H]2CCC3=C([C@]2(CC[C@@H]1O)C)CC[C@]4([C@H]3CC[C@@H]4[C@H](C)CCC(=C)C(C)C)C
InChI
 
  • 1S/C29H48O/c1-18(2)19(3)8-9-20(4)23-12-13-25-22-10-11-24-21(5)27(30)15-17-29(24,7)26(22)14-16-28(23,25)6/h18,20-21,23-25,27,30H,3,8-17H2,1-2,4-7H3/t20-,21+,23-,24+,25+,27+,28-,29+/m1/s1
InChIKey QLDNWJOJCDIMKK-XLFBYWHPSA-N
ChEBI 80094
KEGG C15776
性质
化学式 C29H48O
摩尔质量 412.69 g·mol−1
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

4α-甲基粪生甾醇(英語:4α-methylfecosterol,或称作4α-甲基-5α-麦角甾-8(9),24(28)-二烯-3β-醇,4α-Methyl-5α-ergosta-8(9),24(28)-dien-3β-ol,分子式C29H48O)是真菌甾醇代谢中间产物,可由HYD1改变双键位置转化为24-亚甲基冠影掌烯醇,或发生4-去甲基化生成粪生甾醇[1][2]

参考文献

  1. ^ Kuchta, T; Bartková, K; Kubinec, R. Ergosterol depletion and 4-methyl sterols accumulation in the yeast Saccharomyces cerevisiae treated with an antifungal, 6-amino-2-n-pentylthiobenzothiazole.. Biochemical and biophysical research communications. 30 November 1992, 189 (1): 85–91. PMID 1449509. doi:10.1016/0006-291x(92)91529-y. 
  2. ^ Kuchta, T; Léka, C; Farkas, P; Bujdáková, H; Belajová, E; Russell, NJ. Inhibition of sterol 4-demethylation in Candida albicans by 6-amino-2-n-pentylthiobenzothiazole, a novel mechanism of action for an antifungal agent.. Antimicrobial agents and chemotherapy. July 1995, 39 (7): 1538–41. PMID 7492100. doi:10.1128/aac.39.7.1538可免费查阅.