1,3,4-𫫇二唑
1,3,4-𫫇二唑 | |
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IUPAC名 1,3,4-Oxadiazole 1,3,4-𫫇二唑 | |
识别 | |
CAS号 | 288-99-3 |
PubChem | 97428 |
ChemSpider | 87937 |
SMILES |
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性质 | |
化学式 | C2H2N2O |
摩尔质量 | 70.05 g·mol−1 |
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。 |
1,3,4-𫫇二唑是一种含氮和氧的杂环化合物,是𫫇二唑的四种异构体之一。[1][2]
衍生物
1,3,4-𫫇二唑本身在有机化学中并不常用,但它的许多衍生物很重要。例如,拉替拉韦是一种含有1,3,4-𫫇二唑环的HIV药物。其他含有1,3,4-𫫇二唑环的药物包括酚二唑、齐泊腾坦和硫达唑嗪。
1,3,4-𫫇二唑衍生物可以通过多种方式合成。[3]一种途径是在醛存在下氧化四唑。[4]类似地,四唑与酰氯反应生成𫫇二唑。[5]这两种方法都涉及N2的释放。
参见
- 呋咱(1,2,5-𫫇二唑)
参考资料
- ^ PubChem. 1,3,4-Oxadiazole. pubchem.ncbi.nlm.nih.gov. National Center for Biotechnology Information, U.S. National Library of Medicine. [2019-07-22]. (原始内容存档于2023-05-12) (英语).
- ^ Bala, Suman; Kamboj, Sunil; Kajal, Anu; Saini, Vipin; Prasad, Deo Nanadan. 1,3,4-Oxadiazole Derivatives: Synthesis, Characterization, Antimicrobial Potential, and Computational Studies. BioMed Research International. 2014, 2014: 172791. PMC 4131560
. PMID 25147788. doi:10.1155/2014/172791
.
- ^ 1,3,4-Oxadiazole synthesis. www.organic-chemistry.org. [2018-11-11]. (原始内容存档于2023-05-17).
- ^ Wang, Liang; Cao, Jing; Chen, Qun; He, Mingyang. One-Pot Synthesis of 2,5-Diaryl 1,3,4-Oxadiazoles via Di-tert-butyl Peroxide Promoted Acylation of Aryl Tetrazoles with Aldehydes. The Journal of Organic Chemistry. 2015-04-17, 80 (9): 4743–4748. PMID 25860162. doi:10.1021/acs.joc.5b00207.
- ^ Wong, Michael Y.; Krotkus, Simonas; Copley, Graeme; Li, Wenbo; Murawski, Caroline; Hall, David; Hedley, Gordon J.; Jaricot, Marie; Cordes, David B.; Slawin, Alexandra M. Z.; Olivier, Yoann; Beljonne, David; Muccioli, Luca; Moral, Monica; Sancho-Garcia, Juan-Carlos; Gather, Malte C.; Samuel, Ifor D. W.; Zysman-Colman, Eli. Deep-Blue Oxadiazole-Containing Thermally Activated Delayed Fluorescence Emitters for Organic Light-Emitting Diodes. ACS Applied Materials & Interfaces. 2018-09-07, 10 (39): 33360–33372. PMID 30192504. doi:10.1021/acsami.8b11136. hdl:10023/18433
.