甘氨酰甘氨酸
(重定向自雙甘氨肽)
甘氨酰甘氨酸 | |
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![]() | |
IUPAC名 Glycylglycine | |
系统名 (2-Aminoacetamido)acetic acid | |
别名 |
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识别 | |
缩写 | Gly-Gly |
CAS号 | 556-50-3 ![]() |
PubChem | 11163 |
ChemSpider | 10690 |
SMILES |
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Beilstein | 1765223 |
Gmelin | 82735 |
3DMet | B00385 |
EINECS | 209-127-8 |
ChEBI | 17201 |
KEGG | C02037 |
MeSH | Glycylglycine |
性质 | |
化学式 | C4H8N2O3 |
摩尔质量 | 132.12 g·mol−1 |
外观 | White crystals |
溶解性(水) | 132 g L−1 (at 20 °C) |
log P | −2.291 |
pKa | 3.133 |
pKb | 10.864 |
λmax | 260 nm nm |
吸光度 | 0.075 |
热力学 | |
ΔfHm⦵298K | −749.0–−746.4 kJ mol−1 |
ΔcHm⦵ | −1.9710–−1.9684 MJ mol−1 |
S⦵298K | 180.3 J K−1 mol−1 |
热容 | 163.97 J K−1 mol−1 |
危险性 | |
GHS危险性符号![]() | |
GHS提示词 | WARNING |
H-术语 | H319 |
P-术语 | P305+351+338 |
相关物质 | |
相关化合物 | |
相关化学品 | N-Acetylglycinamide |
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。 |
甘氨酰甘氨酸是甘氨酸的二肽,[1]化学式为C4H8N2O3。它最初于1901年由埃米尔·费歇尔和埃内斯特·富尔诺通过在盐酸中煮沸哌嗪-2,5-二酮制得。[2]
它的毒性低,可用作生物体系的缓冲液,其pH位于2.5~3.8及7.5~8.9之间,[3]但其溶解后仅具有一般的稳定性。[4]
参考文献
- ^ von Richter, Victor. R. Anschütz and G. Shroeter , 编. Richter's organic chemistry. I. Chemistry of the aliphatic series. Translated and revised by Percy E. Spielman after Edgar F. Smith 3rd American. Philadelphia: P. Blakiston's Son & Co. 1916: 391 [July 15, 2010].
- ^ R.H.A. Plimmer. R.H.A. Plimmer & F.G. Hopkins , 编. The chemical composition of the proteins. Monographs on biochemistry. Part II 1st. London: Longmans, Green and Co. July 2008: 22 [1908] [July 15, 2010]. ISBN 978-1-4097-9725-8.
- ^ Biological buffers. Sigma-Aldrich. 2010 [August 9, 2010].
- ^ Smith, Marshall E.; Smith, Lynwood B. Piperazine dihydrochloride and glycylglycine as non-toxic buffers in distilled water and sea water (PDF). The Biological Bulletin (Woods Hole, MA: Marine Biological Laboratory). June 1, 1949, 96 (3): 233–237 [August 9, 2010]. ISSN 0006-3185. JSTOR 1538357. PMID 18153110. doi:10.2307/1538357.