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血小板衍生生長因子受體

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血小板衍生生長因子受體的α鏈英语PDGFRA
識別
符號 PDGFRA
Entrez 5156
HUGO 8803
OMIM 173490
RefSeq NM_006206
UniProt P16234
其他資料
基因座 4 q12
血小板衍生生長因子受體的β鏈英语PDGFRB
Ribbon image of two molecules of human PDGF receptor beta (yellow and magenta) in complex with dimeric PDGF-B (cyan and green).[1]
識別
符號 PDGFRB
替換符號 PDGFR
Entrez 5159
HUGO 8804
OMIM 173410
RefSeq NM_002609
UniProt P09619
其他資料
基因座 5 q31-q32

血小板衍生生長因子受體(Platelet-derived growth factor receptors,PDGF-R)為血小板衍生生長因子(PDGF)蛋白質家族的受體,位於細胞膜表面,屬於酪胺酸激酶受體英语receptor tyrosine kinase的一種。PDGF的次單元A次單元B在調控細胞增殖分化生長發育上扮演相當重要的角色。如果調控不正常,可能會引發癌症等多種疾病。[2]

PDGF-R有兩種型態,分別為AB,兩種型態來自於不同基因。[3]由於PDRF-R必須由兩者結合成為雙體之後才能作用,因此PDGFRA和PDGFRB可以互相組合或自我組合為均聚物(homodimerizes,即A配A、B配B)或雜二聚物(heterodimerizes,即A配B)[4]

參見

參考資料

  1. ^ PDB 3MJG; Shim, Ann Hye-Ryong; Liu, Heli; Focia, Pamela J.; Chen, Xiaoyan; Lin, P. Charles; He, Xiaolin. Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex. Proceedings of the National Academy of Sciences. 2010, 107 (25): 11307–12. ISSN 0027-8424. PMC 2895058可免费查阅. PMID 20534510. doi:10.1073/pnas.1000806107. ; rendered using PyMOL页面存档备份,存于互联网档案馆).
  2. ^ Williams LT. Signal transduction by the platelet-derived growth factor receptor. Science. March 1989, 243 (4898): 1564–70. PMID 2538922. doi:10.1126/science.2538922. 
  3. ^ Heldin CH, Westermark B. Platelet-derived growth factor: three isoforms and two receptor types. Trends Genet. April 1989, 5 (4): 108–11. PMID 2543106. doi:10.1016/0168-9525(89)90040-1. 
  4. ^ Heldin CH, Ostman A, Eriksson A, Siegbahn A, Claesson-Welsh L, Westermark B. Platelet-derived growth factor: isoform-specific signalling via heterodimeric or homodimeric receptor complexes. Kidney Int. March 1992, 41 (3): 571–4. PMID 1315403. doi:10.1038/ki.1992.84. 

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