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戊酸雌二醇/醋酸环丙孕酮

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戊酸雌二醇/醋酸环丙孕酮
戊酸雌二醇(顶部)和醋酸环丙孕酮(下)
组成
戊酸雌二醇雌激素
醋酸环丙孕酮孕激素
臨床資料
商品名英语Drug nomenclature克龄蒙(Climen),Femilar
其他名稱EV/CPA
给药途径口服
藥物類別英语Drug class雌激素孕激素
法律規範狀態
法律規範
识别信息
CAS号108116-22-9

戊酸雌二醇/醋酸环丙孕酮(英語:Estradiol valerate/cyproterone acetate,简称:EV/CPA),以克龄蒙(英語:Climen)和Femilar等品牌销售,是戊酸雌二醇(EV,一种雌激素)和醋酸环丙孕酮(CPA,一种孕激素)的组合产品,用于绝经期激素治疗和作为妇女避孕药使用,[1]其为口服药。[1]克龄蒙用于绝经期激素治疗,是一种序贯制剂,含有2毫克EV和1毫克CPA。[2][3][4]它是第一个上市的用于绝经期激素治疗的含有CPA的产品[3],在40多个国家有售。[2]Femilar是一种含雌二醇的避孕药,含有1至2毫克EV和1至2毫克CPA,自1993年以来在芬兰被批准使用。[5]

一项研究发现,单用CPA在0.5毫克/天的剂量下,5名妇女中有3名抑制排卵,在1毫克/天的剂量下,5名妇女中有5名抑制排卵。[6][7][8][9][10][11]在一项研究中,108名妇女中有94.4%在第三个治疗周期内发生Femilar的排卵抑制,在另一项研究中,26名妇女在12个治疗周期内几乎100%发生排卵抑制(除了一名妇女在第一个治疗周期内排了卵)。[5][12][1]

外部連結

参考文献

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  2. ^ 2.0 2.1 Husmann, Friedrich. Clinical Experiences with a Combination of Estradiol Valerate and Cyproterone Acetate for Hormone Replacement. Women's Health and Menopause. Medical Science Symposia Series 11. 1997: 257–261. ISBN 978-94-010-6343-2. ISSN 0928-9550. doi:10.1007/978-94-011-5560-1_38. 
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