奥昔非君
 | |
| 臨床資料 | |
|---|---|
| AHFS/Drugs.com | 国际药品名称 |
| ATC碼 | |
| 识别信息 | |
| |
| CAS号 | 15687-41-9  |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| KEGG | |
| CompTox Dashboard (EPA) | |
| 化学信息 | |
| 化学式 | C19H23NO3 |
| 摩尔质量 | 313.40 g·mol−1 |
| 3D模型（JSmol） | |
| |
| |
奥昔非君（INN：oxyfedrine）是一种血管扩张剂[1]和β肾上腺素受体激动剂。[2][3]
研究发现，它可以抑制冠状血管的张力，[4]改善心肌代谢（使心脏更好地撑过缺氧），并发挥正变时和正性肌力作用，从而避免诱发心绞痛。[4][5]正性变时性和正性肌力作用尤其重要，因为用于心绞痛的其他血管扩张剂可能会适得其反，导致冠状动脉窃血现象。[6]
有研究提出奥昔非君可与抗生素产生协同作用。[7]
合成
参考资料
- ^ Otsuki, Yuji; Yamasaki, Juntaro; Suina, Kentaro; Okazaki, Shogo; Koike, Naoyoshi; Saya, Hideyuki; Nagano, Osamu. Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy. Cancer Science. 2020-01, 111 (1). ISSN 1349-7006. PMC 6942438
. PMID 31692172. doi:10.1111/cas.14224.
- ^ Sakai, Kazushige; Shiraki, Yasuyuki; Hashimoto, Koroku. An analysis of the ß-adrenergic action of oxyfedrine. European Journal of Pharmacology. 1973-01-01, 21 (1). ISSN 0014-2999. doi:10.1016/0014-2999(73)90210-0.
- ^ Beckett, P. R.; Foster, R. W. Oxyfedrine — A partial agonist at β-adrenoceptors. European Journal of Pharmacology. 1972-11-01, 20 (2). ISSN 0014-2999. doi:10.1016/0014-2999(72)90145-8.
- ^ 4.0 4.1 Chichkanov, G. G.; Chumburidze, V. B. [Mechanism of the antianginal action of oxyfedrine]. Farmakologiia I Toksikologiia. 1977, 40 (3). ISSN 0014-8318. PMID 20326.
- ^ Jc, Kaski; L, Araujo; A, Maseri. Effects of oxyfedrine on regional myocardial blood flow in patients with coronary artery disease. Cardiovascular drugs and therapy. 1991 Dec, 5 (6). ISSN 0920-3206. PMID 1801897. doi:10.1007/BF00143526 （英语）.
- ^ Chichkanov, G. G.; Bogolepov, A. K.; Matsievskiĭ, D. D. [Mechanism of the effect of anti-angina drugs with adrenergic beta receptor agonist action on the collateral hemodynamics and redistribution of the blood flow in chronic myocardial ischemia]. Kardiologiia. 1981-10, 21 (10). ISSN 0022-9040. PMID 6117671.
- ^ Mazumdar K, Dutta NK, Kumar KA, Dastidar SG. In vitro and in vivo synergism between tetracycline and the cardiovascular agent oxyfedrine HCl against common bacterial strains. Biological & Pharmaceutical Bulletin. April 2005, 28 (4): 713–7. PMID 15802815. doi:10.1248/bpb.28.713 .
- ^ Thiele Kurt, 美國專利第3,225,095号 (1965 to Degussa).
| |||||||||||||||||||||||||||||||||||||||