去甲腎上腺素轉運體
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(重定向自去甲肾上腺素转运蛋白)
去甲腎上腺素轉運體(英語:Norepinephrine_transporter,NET),也被稱為溶質載體家族6成員2(英語:solute carrier family 6 member 2,SLC6A2),是由SLC6A2基因編碼的蛋白質。[6]。NET是一种單胺轉運體,負責依賴Na+/Cl−的胞外去甲腎上腺素再攝取。NET也可轉運多巴胺。對這兩種神经递质的再吸收是調控突觸間隙傳導物濃度的重要機制。
NET以及其他單胺轉運體是不少抗抑鬱劑以及娛樂性藥物的作用對象。過少的NET跟直立不耐症相關,過多NET則和ADHD相關。[7][8]
參見
参考资料
- ^ 對Solute carrier family 6 member 2起作用的藥物;在維基數據上查看/編輯參考.
- ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000103546 - Ensembl, May 2017
- ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000055368 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Pacholczyk T, Blakely RD, Amara SG. Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature. Mar 1991, 350 (6316): 350–4. PMID 2008212. doi:10.1038/350350a0.
- ^ Schroeter S, Apparsundaram S, Wiley RG, Miner LH, Sesack SR, Blakely RD. Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporter. The Journal of Comparative Neurology. May 2000, 420 (2): 211–32. PMID 10753308. doi:10.1002/(SICI)1096-9861(20000501)420:2<211::AID-CNE5>3.0.CO;2-3.
- ^ Tellioglu T, Robertson D. Genetic or acquired deficits in the norepinephrine transporter: current understanding of clinical implications. Expert Reviews in Molecular Medicine. Nov 2001, 2001 (29): 1–10. PMID 14987367. doi:10.1017/S1462399401003878.
外部链接
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