丙咪嗪

维基百科，自由的百科全书
丙咪嗪
臨床資料
商品名（英语：Drug nomenclature）Tofranil, Tofranil-PM, others
其他名稱Melipramine; G-22355
AHFS/Drugs.comMonograph
MedlinePlusa682389
核准狀況
懷孕分級
给药途径By mouth, intramuscular injection
ATC碼
法律規範狀態
法律規範
藥物動力學數據
生物利用度94–96%[2]
血漿蛋白結合率86%[3]
药物代谢Liver (CYP1A2, CYP2C19, CYP2D6)[3]
代謝產物Desipramine[3]
生物半衰期20 hours[3]
排泄途徑Kidney (80%), fecal (20%)[3]
识别信息
  • 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
CAS号50-49-7  checkY
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB配體ID
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)
ECHA InfoCard100.000.039 編輯維基數據鏈接
化学信息
化学式C19H24N2
摩尔质量280.42 g·mol−1
3D模型（JSmol（英语：JSmol））
  • CN(C)CCCN1c2ccccc2CCc2ccccc21
  • InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 checkY
  • Key:BCGWQEUPMDMJNV-UHFFFAOYSA-N checkY

丙咪嗪是一种口服三环类抗抑郁药，主要用于治疗抑鬱。它还可以治疗焦慮和恐慌症。[5][6][7]

丙咪嗪的常见副作用有口乾、昏睡、頭暈、低血壓、心跳过速、尿瀦留。丙咪嗪过量可能會导致死亡。

丙咪嗪于1951年被发现，并于1957年投入臨床使用。

参考文献

  1. ^ Imipramine Use During Pregnancy. Drugs.com. 28 August 2019 [7 February 2020]. 
  2. ^ Heck HA, Buttrill SE, Flynn NW, Dyer RL, Anbar M, Cairns T, et al. Bioavailability of imipramine tablets relative to a stable isotope-labeled internal standard: increasing the power of bioavailability tests. Journal of Pharmacokinetics and Biopharmaceutics. June 1979, 7 (3): 233–248. PMID 480146. S2CID 23232584. doi:10.1007/BF01060015. 
  3. ^ 3.0 3.1 3.2 3.3 3.4 Product Information Tolerade (imipramine hydrochloride). TGA eBusiness Services. PMIP Pty Ltd. 4 June 2013 [16 October 2013]. （原始内容存档于10 December 2019）. 
  4. ^ Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-03-31 (2023-04-04) [2023-08-16]. （原始内容存档于2023-08-03） （巴西葡萄牙语）. 
  5. ^ Robert R, Blakeney PE, Villarreal C, Rosenberg L, Meyer WJ. Imipramine treatment in pediatric burn patients with symptoms of acute stress disorder: a pilot study. Journal of the American Academy of Child and Adolescent Psychiatry. July 1999, 38 (7): 873–882. PMID 10405506. doi:10.1097/00004583-199907000-00018. 
  6. ^ Tcheung WJ, Robert R, Rosenberg L, Rosenberg M, Villarreal C, Thomas C, et al. Early treatment of acute stress disorder in children with major burn injury. Pediatric Critical Care Medicine. November 2005, 6 (6): 676–681. PMID 16276335. S2CID 43261789. doi:10.1097/01.pcc.0000165562.04157.da. 
  7. ^ Robert R, Tcheung WJ, Rosenberg L, Rosenberg M, Mitchell C, Villarreal C, et al. Treating thermally injured children suffering symptoms of acute stress with imipramine and fluoxetine: a randomized, double-blind study. Burns. November 2008, 34 (7): 919–928. PMID 18675519. doi:10.1016/j.burns.2008.04.009. 
取自“https://zh.wikipedia.org/w/index.php?title=丙咪嗪&oldid=79825756”