上皮细胞黏附分子

EPCAM
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4MZV
識別號
别名	EPCAM；, DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1, epithelial cell adhesion molecule, BerEp4, MOC-31, Ber-Ep4
外部ID	OMIM：185535 MGI：106653 HomoloGene：1764 GeneCards：EPCAM
相關疾病
	congenital diarrhea 5 with tufting enteropathy
基因位置（人类）
染色体	2號染色體
终止	47,387,601 bp
基因位置（小鼠）
染色体	小鼠17号染色体
终止	87,958,557 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• 大分子复合物结合; • 血浆蛋白结合; • cadherin binding involved in cell-cell adhesion;
細胞組分	• integral component of membrane; • lateral plasma membrane; • 膜; • 双细胞紧密连接; • 细胞膜; • cell surface; • 细胞连接; • basolateral plasma membrane; • apical plasma membrane; • 外排體; • integral component of plasma membrane;
生物學過程	• ureteric bud development; • positive regulation of cell motility; • negative regulation of cell-cell adhesion mediated by cadherin; • signal transduction involved in regulation of gene expression; • negative regulation of apoptotic process; • stem cell differentiation; • positive regulation of cell population proliferation; • positive regulation of stem cell proliferation; • positive regulation of transcription by RNA polymerase II; • leukocyte migration; • cell-cell adhesion via plasma-membrane adhesion molecules;
	Sources:Amigo / QuickGO
直系同源
	4072
	17075
	ENSG00000119888
	ENSMUSG00000045394
	P16422
	Q99JW5
	NM_002354
	NM_008532
	NP_002345
	NP_032558
	維基數據
檢視/編輯人類	檢視/編輯小鼠

上皮细胞黏附分子（英語：Epithelial cell adhesion molecule，缩写EpCAM，也称为CD326，cluster of differentiation 326，分化簇326）是一种细胞表面跨膜醣蛋白，由人类2号染色体上的基因 EPCAM 编码，属于非钙依赖类细胞黏附分子，是上皮细胞的主要标志物^[6]。

参考文献

^ 與EPCAM相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000119888 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000045394 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Litvinov SV, Velders MP, Bakker HA, Fleuren GJ, Warnaar SO. Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule. The Journal of Cell Biology. April 1994, 125 (2): 437–46. PMC 2120036 . PMID 8163559. doi:10.1083/jcb.125.2.437.

外部链接

FAQs on HNPCC 互联网档案馆的存檔，存档日期15 August 2007. from the National Institute of Health
GeneReviews/NCBI/NIH/UW entry on Lynch syndrome
醫學主題詞表（MeSH）：TACSTD1+protein,+human

上皮细胞黏附分子引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。

[1] 與EPCAM相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000119888 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000045394 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[Litvinov1994-6] Litvinov SV, Velders MP, Bakker HA, Fleuren GJ, Warnaar SO. Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule. The Journal of Cell Biology. April 1994, 125 (2): 437–46. PMC 2120036 . PMID 8163559. doi:10.1083/jcb.125.2.437.

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